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This is a phenotypic model of a kinetic proofreading mechanism used to describe dynamics governing interactions between T cell receptors and peptide-MHC complexes. It can be used to explore systemsbiology lever2014 phenotypic of t cell dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_model_state_c0",
"label": "Initial Model State C0",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c0",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C0`."
},
{
"name": "initial_model_state_c9",
"label": "Initial Model State C9",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c9",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9`."
},
{
"name": "initial_model_state_c8",
"label": "Initial Model State C8",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c8",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C8`."
},
{
"name": "initial_model_state_c7",
"label": "Initial Model State C7",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c7",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C7`."
},
{
"name": "initial_model_state_c6",
"label": "Initial Model State C6",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c6",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C6`."
},
{
"name": "initial_model_state_c5",
"label": "Initial Model State C5",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.initial_model_state_c5",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C5`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.summary"
},
{
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},
{
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},
{
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},
{
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{
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},
{
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"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.model_state_c6"
},
{
"name": "model_state_c5",
"maps_to": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.model_state_c5"
}
]
},
"tags": [
"immunology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Lever2014 Phenotypic Models Of T Cell Activation Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
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},
{
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],
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},
{
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"from": "systemsbiology_sbml_lever2014_phenotypic_models_of_t_cell_activation_model1907260003_model.species_labels"
}
],
"package": "lever2014-phenotypic-models-of-t-cell-activation",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is a phenotypic model of a kinetic proofreading mechanism used to describe dynamics governing interactions between T cell receptors and peptide-MHC complexes. It can be used to explore systemsbiology lever2014 phenotypic of t cell dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagelever2014-phenotypic-models-of-t-cell-activation
Created2026-05-17
Updated2026-06-13
immunologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother