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This sbml file describes the RECI model from: 'Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system' by Bernhard Schmierer, Alexander L. It can be used to explore systemsbiology schmierer 2008 smad tgfb BioModels0000000173 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_smad2_c",
"label": "Initial Smad2 C",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad2_c",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S2_c`."
},
{
"name": "initial_gfp_smad2_c",
"label": "Initial Gfp Smad2 C",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_gfp_smad2_c",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `G_c`."
},
{
"name": "initial_smad4_c",
"label": "Initial Smad4 C",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad4_c",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S4_c`."
},
{
"name": "initial_smad4_n",
"label": "Initial Smad4 N",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad4_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S4_n`."
},
{
"name": "initial_smad2_n",
"label": "Initial Smad2 N",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_smad2_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `S2_n`."
},
{
"name": "initial_gfp_smad2_n",
"label": "Initial Gfp Smad2 N",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.initial_gfp_smad2_n",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `G_n`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.species_labels"
},
{
"name": "smad2_c",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad2_c"
},
{
"name": "gfp_smad2_c",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.gfp_smad2_c"
},
{
"name": "smad4_c",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad4_c"
},
{
"name": "smad4_n",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad4_n"
},
{
"name": "smad2_n",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.smad2_n"
},
{
"name": "gfp_smad2_n",
"maps_to": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.gfp_smad2_n"
}
]
},
"tags": [
"signaling",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Schmierer2008 Smad Tgfb Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_state"
],
"from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_summary"
],
"from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model_species_labels"
],
"from": "systemsbiology_sbml_schmierer_2008_smad_tgfb_biomd0000000173_model.species_labels"
}
],
"package": "schmierer2008-smad-tgfb",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This sbml file describes the RECI model from: 'Mathematical modeling identifies Smad nucleocytoplasmic shuttling as a dynamic signal-interpreting system' by Bernhard Schmierer, Alexander L. It can be used to explore systemsbiology schmierer 2008 smad tgfb BioModels0000000173 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageschmierer2008-smad-tgfb
Created2026-05-17
Updated2026-06-13
signalingsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother