Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling Lab
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Clean Biosimulant lab for circadian regulatory signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_kact_tgf_beta_level",
"label": "Kact TGF-beta",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_kact_tgf_beta_level",
"description": "Kact TGF-beta source parameter. Maps to SBML symbol `kactTgfb` and preserves the bundled default."
},
{
"name": "initial_sink_species",
"label": "Initial sink species",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_sink_species",
"description": "Initial level of sink species. Maps to SBML symbol `Sink`; exposed as a traceable initial-condition perturbation."
},
{
"name": "initial_source",
"label": "Initial Source",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.initial_source",
"description": "Initial level of Source. Maps to SBML symbol `Source`; exposed as a traceable initial-condition perturbation."
}
],
"outputs": [
{
"name": "source_defined_bone_state",
"label": "Source Defined BONE State",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_bone_state",
"description": "Source Defined BONE State. Maps to SBML symbol `Bone` and is emitted in native SBML units."
},
{
"name": "source_defined_hsc_state",
"label": "Source Defined HSC State",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_hsc_state",
"description": "Source Defined HSC State. Maps to SBML symbol `HSC` and is emitted in native SBML units."
},
{
"name": "source_defined_ob_m_state",
"label": "Source Defined OB M State",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.source_defined_ob_m_state",
"description": "Source Defined OB M State. Maps to SBML symbol `Ob_m` and is emitted in native SBML units."
},
{
"name": "state",
"label": "Observable state",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.species_labels"
}
]
},
"tags": [
"signaling",
"systems",
"systems-biology",
"sbml",
"faithful",
"biomodels_ebi",
"circadian",
"physiology"
],
"title": "Proctor2016 - Circadian rhythm of PTH and the dynamics of signaling molecules on bone remodeling Lab",
"models": [
{
"path": "models/core",
"alias": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_state"
],
"from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.state"
},
{
"to": [
"visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_summary"
],
"from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.summary"
},
{
"to": [
"visualisation.signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model_species_labels"
],
"from": "signaling_sbml_proctor2016_circadian_rhythm_of_pth_and_the_dyna_biomd0000000612_model.species_labels"
}
],
"package": "proctor2016-circadian-rhythm-of-pth-and-the-dyna",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Clean Biosimulant lab for circadian regulatory signaling. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageproctor2016-circadian-rhythm-of-pth-and-the-dyna
Created2026-05-16
Updated2026-06-13
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebicircadianphysiologyvisualisationother