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Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_epithelial_cells_with_bacteria_attached_ea",
"label": "Initial Epithelial Cells With Bacteria Attached Ea",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_epithelial_cells_with_bacteria_attached_ea",
"description": "Initial Epithelial Cells With Bacteria Attached Ea. Sets the initial value of bundled SBML species `Epithelial_cells_with_bacteria_attached__Ea`."
},
{
"name": "initial_pneumococci_p",
"label": "Initial Pneumococci P",
"units": "substance",
"default": 100000,
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_pneumococci_p",
"description": "Initial Pneumococci P. Sets the initial value of bundled SBML species `Pneumococci___P`."
},
{
"name": "initial_susceptible_epithelial_cells_eu",
"label": "Initial Susceptible Epithelial Cells Eu",
"units": "substance",
"default": 100000000,
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_susceptible_epithelial_cells_eu",
"description": "Initial Susceptible Epithelial Cells Eu. Sets the initial value of bundled SBML species `Susceptible_epithelial_cells__EU`."
},
{
"name": "initial_proinflammatory_cytokine_c",
"label": "Initial Proinflammatory Cytokine C",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_proinflammatory_cytokine_c",
"description": "Initial Proinflammatory Cytokine C. Sets the initial value of bundled SBML species `proinflammatory_cytokine__C`."
},
{
"name": "initial_neutrophils_n",
"label": "Initial Neutrophils N",
"units": "substance",
"default": 0,
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.initial_neutrophils_n",
"description": "Initial Neutrophils N. Sets the initial value of bundled SBML species `Neutrophils__N`."
}
],
"outputs": [
{
"name": "epithelial_cells_with_bacteria_attached_ea",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.epithelial_cells_with_bacteria_attached_ea"
},
{
"name": "pneumococci_p",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.pneumococci_p"
},
{
"name": "susceptible_epithelial_cells_eu",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.susceptible_epithelial_cells_eu"
},
{
"name": "proinflammatory_cytokine_c",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.proinflammatory_cytokine_c"
},
{
"name": "neutrophils_n",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.neutrophils_n"
},
{
"name": "state",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.species_labels"
}
]
},
"title": "Smith2011 - Three Stage Innate Immune Response to a Pneumococcal Lung Infection Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_state"
],
"from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.state"
},
{
"to": [
"visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_summary"
],
"from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model_species_labels"
],
"from": "immunology_sbml_smith2011_three_stage_innate_immune_response_to_biomd0000000924_model.species_labels"
}
],
"package": "smith2011-three-stage-innate-immune-response-to-a",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Pneumococcal pneumonia is a leading cause of death and a major source of human morbidity. The initial immune response plays a central role in determining the course and outcome of pneumococcal disease.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagesmith2011-three-stage-innate-immune-response-to-a
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother