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Ribba2012 - Low-grade gliomas, tumour growth inhibition model Using longitudinal mean tumour diameter (MTD) data, this model describe the size evolution of low-grade glioma (LGG) in patients treated w. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_damaged_quiescent_cells",
"label": "Damaged quiescent cells",
"units": "native SBML value",
"default": 0,
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.initial_damaged_quiescent_cells",
"description": "Initial Damaged quiescent cells. Sets the initial value of bundled SBML symbol `Qp`."
},
{
"name": "initial_pcv_plasma",
"label": "PCV plasma",
"units": "native SBML value",
"default": 1,
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.initial_pcv_plasma",
"description": "Initial PCV plasma. Sets the initial value of bundled SBML symbol `C`."
},
{
"name": "initial_proliferative_tissue",
"label": "Proliferative tissue",
"units": "native SBML value",
"default": 7.13,
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.initial_proliferative_tissue",
"description": "Initial Proliferative tissue. Sets the initial value of bundled SBML symbol `P`."
},
{
"name": "initial_nonproliferative_quiescent_tissue",
"label": "Nonproliferative quiescent tissue",
"units": "native SBML value",
"default": 41.2,
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.initial_nonproliferative_quiescent_tissue",
"description": "Initial Nonproliferative quiescent tissue. Sets the initial value of bundled SBML symbol `Q`."
}
],
"outputs": [
{
"name": "damaged_quiescent_cells",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.damaged_quiescent_cells",
"description": "Damaged quiescent cells observable. Maps to SBML symbol `Qp`."
},
{
"name": "pcv_plasma",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.pcv_plasma",
"description": "PCV plasma observable. Maps to SBML symbol `C`."
},
{
"name": "proliferative_tissue",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.proliferative_tissue",
"description": "Proliferative tissue observable. Maps to SBML symbol `P`."
},
{
"name": "nonproliferative_quiescent_tissue",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.nonproliferative_quiescent_tissue",
"description": "Nonproliferative quiescent tissue observable. Maps to SBML symbol `Q`."
},
{
"name": "state",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"curated",
"drug-response",
"faithful",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Ribba2012 - Low-grade gliomas, tumour growth inhibition model Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model_state"
],
"from": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.state"
},
{
"to": [
"visualisation.oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model_summary"
],
"from": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model_species_labels"
],
"from": "oncology_sbml_ribba2012_low_grade_gliomas_tumour_growth_inhibi_biomd0000000521_model.species_labels"
}
],
"package": "ribba2012-low-grade-gliomas-tumour-growth-inhibition",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Ribba2012 - Low-grade gliomas, tumour growth inhibition model Using longitudinal mean tumour diameter (MTD) data, this model describe the size evolution of low-grade glioma (LGG) in patients treated w. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageribba2012-low-grade-gliomas-tumour-growth-inhibition
Created2026-05-16
Updated2026-06-13
biomodels_ebicurateddrug-responsefaithfuloncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother