Bachmann2011 - Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_erythropoietin_receptor_jak2_complex",
        "label": "Initial Erythropoietin Receptor Jak2 Complex",
        "units": "native source value",
        "default": 3.97622,
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.initial_erythropoietin_receptor_jak2_complex",
        "description": "Initial Erythropoietin Receptor Jak2 Complex. Sets the initial value of bundled SBML species `EpoRJAK2`."
      },
      {
        "name": "initial_phosphorylated_erythropoietin_receptor_jak2_complex",
        "label": "Initial Phosphorylated Erythropoietin Receptor Jak2 Complex",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.initial_phosphorylated_erythropoietin_receptor_jak2_complex",
        "description": "Initial Phosphorylated Erythropoietin Receptor Jak2 Complex. Sets the initial value of bundled SBML species `EpoRpJAK2`."
      },
      {
        "name": "initial_phosphorylated_erythropoietin_receptor_jak2_site_1",
        "label": "Initial Phosphorylated Erythropoietin Receptor Jak2 Site 1",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.initial_phosphorylated_erythropoietin_receptor_jak2_site_1",
        "description": "Initial Phosphorylated Erythropoietin Receptor Jak2 Site 1. Sets the initial value of bundled SBML species `p1EpoRpJAK2`."
      },
      {
        "name": "initial_phosphorylated_erythropoietin_receptor_jak2_site_2",
        "label": "Initial Phosphorylated Erythropoietin Receptor Jak2 Site 2",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.initial_phosphorylated_erythropoietin_receptor_jak2_site_2",
        "description": "Initial Phosphorylated Erythropoietin Receptor Jak2 Site 2. Sets the initial value of bundled SBML species `p2EpoRpJAK2`."
      },
      {
        "name": "initial_phosphorylated_erythropoietin_receptor_jak2_sites_1_2",
        "label": "Initial Phosphorylated Erythropoietin Receptor Jak2 Sites 1 2",
        "units": "native source value",
        "default": 0,
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.initial_phosphorylated_erythropoietin_receptor_jak2_sites_1_2",
        "description": "Initial Phosphorylated Erythropoietin Receptor Jak2 Sites 1 2. Sets the initial value of bundled SBML species `p12EpoRpJAK2`."
      }
    ],
    "outputs": [
      {
        "name": "erythropoietin_receptor_jak2_complex",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.erythropoietin_receptor_jak2_complex"
      },
      {
        "name": "phosphorylated_erythropoietin_receptor_jak2_complex",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.phosphorylated_erythropoietin_receptor_jak2_complex"
      },
      {
        "name": "phosphorylated_erythropoietin_receptor_jak2_site_1",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.phosphorylated_erythropoietin_receptor_jak2_site_1"
      },
      {
        "name": "phosphorylated_erythropoietin_receptor_jak2_site_2",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.phosphorylated_erythropoietin_receptor_jak2_site_2"
      },
      {
        "name": "phosphorylated_erythropoietin_receptor_jak2_sites_1_2",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.phosphorylated_erythropoietin_receptor_jak2_sites_1_2"
      },
      {
        "name": "state",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.state"
      },
      {
        "name": "summary",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.species_labels"
      }
    ]
  },
  "title": "Bachmann2011 - Division of labor by dual feedback regulators controls JAK2/STAT5 signaling over broad ligand range Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model_state"
      ],
      "from": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.state"
    },
    {
      "to": [
        "visualisation.immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model_summary"
      ],
      "from": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.summary"
    },
    {
      "to": [
        "visualisation.immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model_species_labels"
      ],
      "from": "immunology_sbml_bachmann2011_division_of_labor_by_dual_feedback_biomd0000000861_model.species_labels"
    }
  ],
  "package": "bachmann2011-division-of-labor-by-dual-feedback-regulators",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.1",
  "description": "This is a dynamic pathway model examining the roles of of the two transcriptional negative feedback regulators of the suppressor of cytokine signaling (SOCS) family, CIS and SOCS3, in JAK/STAT5 signal. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
  "schema_version": "2.0"
}