About lab
One published Lab
Build with this Lab. Run it anywhere.
Use the same immutable release locally or through managed cloud execution, with its exact version and provenance preserved.
Preparing exact examples…
Clean Biosimulant lab for systems signaling model: Yan2012 - Rb-E2F pathway dynamics with miR449. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_source_defined_s_state",
"label": "Initial source-defined S state",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.initial_source_defined_s_state",
"description": "Initial level of source-defined S state. Maps to SBML symbol `S`; exposed as a traceable initial-condition perturbation."
}
],
"outputs": [
{
"name": "e2f",
"label": "E2F",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.e2f",
"description": "E2F. Maps to SBML symbol `E2F` and is emitted in native SBML units."
},
{
"name": "myc_transcription_factor",
"label": "MYC transcription factor",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.myc_transcription_factor",
"description": "MYC transcription factor. Maps to SBML symbol `Myc` and is emitted in native SBML units."
},
{
"name": "source_defined_cycd_state",
"label": "source-defined CYCD state",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.source_defined_cycd_state",
"description": "source-defined CYCD state. Maps to SBML symbol `CycD` and is emitted in native SBML units."
},
{
"name": "state",
"label": "Observable state",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.species_labels"
}
]
},
"tags": [
"signaling",
"systems",
"systems-biology",
"sbml",
"faithful",
"biomodels_ebi",
"cellular-signaling"
],
"title": "Yan2012 - Rb-E2F pathway dynamics with miR449 Lab",
"models": [
{
"path": "models/core",
"alias": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model_state"
],
"from": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.state"
},
{
"to": [
"visualisation.signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model_summary"
],
"from": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.summary"
},
{
"to": [
"visualisation.signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model_species_labels"
],
"from": "signaling_sbml_yan2012_rb_e2f_pathway_dynamics_with_mir449_biomd0000000720_model.species_labels"
}
],
"package": "yan2012-rb-e2f-pathway-dynamics-with-mir449",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Clean Biosimulant lab for systems signaling model: Yan2012 - Rb-E2F pathway dynamics with miR449. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageyan2012-rb-e2f-pathway-dynamics-with-mir449
Created2026-05-16
Updated2026-06-13
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebicellular-signalingvisualisationother