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Clean Biosimulant lab for systems signaling model: Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_shear_stress",
"label": "Initial Shear Stress",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.initial_shear_stress",
"description": "Initial level of Shear Stress. Maps to SBML symbol `s119`; exposed as a traceable initial-condition perturbation."
}
],
"outputs": [
{
"name": "akt",
"label": "AKT",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.akt",
"description": "AKT. Maps to SBML symbol `s16` and is emitted in native SBML units."
},
{
"name": "p_akt_pi3p",
"label": "P AKT PI3P",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.p_akt_pi3p",
"description": "P AKT PI3P. Maps to SBML symbol `s26` and is emitted in native SBML units."
},
{
"name": "pp_akt_pi3p",
"label": "Pp AKT PI3P",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.pp_akt_pi3p",
"description": "Pp AKT PI3P. Maps to SBML symbol `s27` and is emitted in native SBML units."
},
{
"name": "state",
"label": "Observable state",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.species_labels"
}
]
},
"tags": [
"signaling",
"systems",
"systems-biology",
"sbml",
"faithful",
"biomodels_ebi",
"pi3k-akt",
"stress-response"
],
"title": "Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2 Lab",
"models": [
{
"path": "models/core",
"alias": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_state"
],
"from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.state"
},
{
"to": [
"visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_summary"
],
"from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.summary"
},
{
"to": [
"visualisation.signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model_species_labels"
],
"from": "signaling_sbml_koo2013_shear_stress_induced_akt_and_enos_phosph_biomd0000000465_model.species_labels"
}
],
"package": "koo2013-shear-stress-induced-akt-and-enos-phosph",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Clean Biosimulant lab for systems signaling model: Koo2013 - Shear stress induced AKT and eNOS phosphorylation - Model 2. Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagekoo2013-shear-stress-induced-akt-and-enos-phosph
Created2026-05-16
Updated2026-06-13
signalingsystemssystems-biologysbmlfaithfulbiomodels_ebipi3k-aktstress-responsevisualisationother