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NCBS Curation Comments This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal trans. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_interferon_receptor_jak_complex",
"label": "Initial Interferon Receptor JAK Complex",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.initial_interferon_receptor_jak_complex",
"description": "Initial Interferon Receptor JAK Complex. Sets the initial value of bundled SBML species `IFNRJ`."
},
{
"name": "initial_receptor_jak_complex",
"label": "Initial Receptor JAK Complex",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.initial_receptor_jak_complex",
"description": "Initial Receptor JAK Complex. Sets the initial value of bundled SBML species `RJ`."
},
{
"name": "initial_ifnrj_dimer",
"label": "Initial Ifnrj Dimer",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.initial_ifnrj_dimer",
"description": "Initial Ifnrj Dimer. Sets the initial value of bundled SBML species `IFNRJ2`."
},
{
"name": "initial_activated_ifnrj_complex",
"label": "Initial Activated Ifnrj Complex",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.initial_activated_ifnrj_complex",
"description": "Initial Activated Ifnrj Complex. Sets the initial value of bundled SBML species `IFNRJ2_star`."
},
{
"name": "initial_interferon_receptor_jak2_stat1_complex",
"label": "Initial Interferon Receptor Jak2 Stat1 Complex",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.initial_interferon_receptor_jak2_stat1_complex",
"description": "Initial Interferon Receptor Jak2 Stat1 Complex. Sets the initial value of bundled SBML species `IFNRJ2_star_STAT1c`."
}
],
"outputs": [
{
"name": "interferon_receptor_jak_complex",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.interferon_receptor_jak_complex"
},
{
"name": "receptor_jak_complex",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.receptor_jak_complex"
},
{
"name": "ifnrj_dimer",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.ifnrj_dimer"
},
{
"name": "activated_ifnrj_complex",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.activated_ifnrj_complex"
},
{
"name": "interferon_receptor_jak2_stat1_complex",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.interferon_receptor_jak2_stat1_complex"
},
{
"name": "state",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.species_labels"
}
]
},
"title": "Yamada2003 JAK STAT pathway Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model_state"
],
"from": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.state"
},
{
"to": [
"visualisation.immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model_summary"
],
"from": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model_species_labels"
],
"from": "immunology_sbml_yamada2003_jak_stat_pathway_biomd0000000093_model.species_labels"
}
],
"package": "yamada2003-jak-stat-pathway",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "NCBS Curation Comments This model shows the control mechanism of Jak-Stat pathway, here SOCS1 (Suppressor of cytokine signaling-I) was identified as the negative regulator of Jak and STAT signal trans. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageyamada2003-jak-stat-pathway
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother