Gulhane2022 - Sphingolipid metabolism and PI3K-AKT axis in NSCLC Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_glucose_metabolism",
        "label": "Glucose Metabolism",
        "units": "native SBML value",
        "default": 518000,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_glucose_metabolism",
        "description": "Initial Glucose Metabolism. Sets the initial value of bundled SBML symbol `mwcc0d0d1e_f9ca_43ca_a94d_dbf4e0efbc13`."
      },
      {
        "name": "initial_ras",
        "label": "Ras",
        "units": "native SBML value",
        "default": 100000,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_ras",
        "description": "Initial Ras. Sets the initial value of bundled SBML symbol `mw338974cb_3199_4092_a3fe_e32b9b3fc4d6`."
      },
      {
        "name": "initial_pi3_k",
        "label": "PI3K",
        "units": "native SBML value",
        "default": 216000,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_pi3_k",
        "description": "Initial PI3K. Sets the initial value of bundled SBML symbol `mw1906ffc7_edd7_4567_8b41_84201e788393`."
      },
      {
        "name": "initial_grb2",
        "label": "GRB2",
        "units": "native SBML value",
        "default": 986,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_grb2",
        "description": "Initial GRB2. Sets the initial value of bundled SBML symbol `mwe5fc6bf1_e5b9_4f84_b107_5828de7af61b`."
      },
      {
        "name": "initial_sos",
        "label": "SOS",
        "units": "native SBML value",
        "default": 986,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_sos",
        "description": "Initial SOS. Sets the initial value of bundled SBML symbol `mw25445311_570d_491b_835f_c395e5a4003a`."
      },
      {
        "name": "initial_irs",
        "label": "IRS",
        "units": "native SBML value",
        "default": 986,
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.initial_irs",
        "description": "Initial IRS. Sets the initial value of bundled SBML symbol `mw36987a2d_4042_4802_add1_f8d289da6b4a`."
      }
    ],
    "outputs": [
      {
        "name": "glucose_metabolism",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.glucose_metabolism",
        "description": "Glucose Metabolism observable. Maps to SBML symbol `mwcc0d0d1e_f9ca_43ca_a94d_dbf4e0efbc13`."
      },
      {
        "name": "ras",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.ras",
        "description": "Ras observable. Maps to SBML symbol `mw338974cb_3199_4092_a3fe_e32b9b3fc4d6`."
      },
      {
        "name": "pi3_k",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.pi3_k",
        "description": "PI3K observable. Maps to SBML symbol `mw1906ffc7_edd7_4567_8b41_84201e788393`."
      },
      {
        "name": "grb2",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.grb2",
        "description": "GRB2 observable. Maps to SBML symbol `mwe5fc6bf1_e5b9_4f84_b107_5828de7af61b`."
      },
      {
        "name": "sos",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.sos",
        "description": "SOS observable. Maps to SBML symbol `mw25445311_570d_491b_835f_c395e5a4003a`."
      },
      {
        "name": "irs",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.irs",
        "description": "IRS observable. Maps to SBML symbol `mw36987a2d_4042_4802_add1_f8d289da6b4a`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "metabolism",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Gulhane2022 - Sphingolipid metabolism and PI3K-AKT axis in NSCLC Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model_state"
      ],
      "from": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model_summary"
      ],
      "from": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model_species_labels"
      ],
      "from": "oncology_sbml_gulhane2022_sphingolipid_metabolism_and_pi3k_akt_model2402290001_model.species_labels"
    }
  ],
  "package": "gulhane2022-sphingolipid-metabolism-and-pi3k-akt-axis-in-nsclc",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "In this model, we demonstrated that the increased expression of sphingolipids enzyme affects PI3K-AKT signaling axis and its downstream signaling mediators resulting in cancer progression. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}