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<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>Optimal control. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor_cells",
"label": "Tumor Cells",
"units": "native SBML value",
"default": 10000000,
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.initial_tumor_cells",
"description": "Initial Tumor Cells. Sets the initial value of bundled SBML symbol `T`."
},
{
"name": "chemotherapy_drug_level",
"label": "Chemotherapy Drug Level",
"units": "native SBML value",
"default": 6.6666657777779e-7,
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.chemotherapy_drug_level",
"description": "Chemotherapy Drug Level. Overrides bundled SBML parameter `D`."
}
],
"outputs": [
{
"name": "tumor_cells",
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.tumor_cells",
"description": "Tumor Cells observable. Maps to SBML symbol `T`."
},
{
"name": "state",
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"chemotherapy",
"curated",
"drug-response",
"faithful",
"immunology",
"immunotherapy",
"microenvironment",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "dePillis2008 - Optimal control of mixed immunotherapy and chemotherapy of tumors Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model_state"
],
"from": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.state"
},
{
"to": [
"visualisation.oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model_summary"
],
"from": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model_species_labels"
],
"from": "oncology_sbml_depillis2008_optimal_control_of_mixed_immunother_biomd0000000913_model.species_labels"
}
],
"package": "depillis2008-optimal-control-of-mixed-immunotherapy-and-0b1f5f8a",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "<notes xmlns="http://www.sbml.org/sbml/level2/version4"> <body xmlns="http://www.w3.org/1999/xhtml"> <pre>Optimal control. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagedepillis2008-optimal-control-of-mixed-immunotherapy-and-0b1f5f8a
Created2026-05-16
Updated2026-06-13
biomodels_ebichemotherapycurateddrug-responsefaithfulimmunologyimmunotherapymicroenvironmentoncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother