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This is a mathematical model investigating the effects of continuous and intermittent PD-L1 and anti-PD-L1 therapy upon tumor-immune dynamics. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_tumor_observable_1",
"label": "Initial Unresolved Tumor Observable 1",
"units": "native source value",
"default": 0.3968,
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.initial_unresolved_tumor_observable_1",
"description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `C`."
},
{
"name": "initial_unresolved_tumor_observable_2",
"label": "Initial Unresolved Tumor Observable 2",
"units": "native source value",
"default": 0.006,
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.initial_unresolved_tumor_observable_2",
"description": "Initial Unresolved Tumor Observable 2. Sets the initial value of bundled SBML species `T`."
},
{
"name": "initial_unresolved_tumor_observable_3",
"label": "Initial Unresolved Tumor Observable 3",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.initial_unresolved_tumor_observable_3",
"description": "Initial Unresolved Tumor Observable 3. Sets the initial value of bundled SBML species `A`."
}
],
"outputs": [
{
"name": "unresolved_tumor_observable_1",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.unresolved_tumor_observable_1"
},
{
"name": "unresolved_tumor_observable_2",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.unresolved_tumor_observable_2"
},
{
"name": "unresolved_tumor_observable_3",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.unresolved_tumor_observable_3"
},
{
"name": "state",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.species_labels"
}
]
},
"title": "Nikolopoulou2018 - Tumour-immune dynamics with an immune checkpoint inhibitor Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model_state"
],
"from": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.state"
},
{
"to": [
"visualisation.immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model_summary"
],
"from": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model_species_labels"
],
"from": "immunology_sbml_nikolopoulou2018_tumour_immune_dynamics_with_an_model1908270001_model.species_labels"
}
],
"package": "nikolopoulou2018-tumour-immune-dynamics-with-an-immune-379b6dab",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a mathematical model investigating the effects of continuous and intermittent PD-L1 and anti-PD-L1 therapy upon tumor-immune dynamics. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagenikolopoulou2018-tumour-immune-dynamics-with-an-immune-379b6dab
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother