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An in silico model to examine damage-induced circadian phase shifts by investigating a possible mechanism linking circadian rhythms to metabolism. The proposed model involves two DNA damage response p.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_metabolic_pathway_state_1",
"units": "native SBML value",
"default": 1.54597010260715,
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.initial_metabolic_pathway_state_1",
"description": "Initial condition for metabolic pathway state 1. Maps to bundled SBML symbol `species_1`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_2",
"units": "native SBML value",
"default": 0.101793613432364,
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.initial_metabolic_pathway_state_2",
"description": "Initial condition for metabolic pathway state 2. Maps to bundled SBML symbol `species_2`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_metabolic_pathway_state_3",
"units": "native SBML value",
"default": 0.0723157888573554,
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.initial_metabolic_pathway_state_3",
"description": "Initial condition for metabolic pathway state 3. Maps to bundled SBML symbol `species_3`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_cp2",
"units": "native SBML value",
"default": 0.0475926846633792,
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.initial_cp2",
"description": "Initial condition for cp2. Maps to bundled SBML symbol `species_4`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
},
{
"name": "initial_nad",
"units": "native SBML value",
"default": 5.20806131539501,
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.initial_nad",
"description": "Initial condition for nad. Maps to bundled SBML symbol `species_5`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
}
],
"outputs": [
{
"name": "metabolic_pathway_state_1",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.metabolic_pathway_state_1"
},
{
"name": "metabolic_pathway_state_2",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.metabolic_pathway_state_2"
},
{
"name": "metabolic_pathway_state_3",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.metabolic_pathway_state_3"
},
{
"name": "cp2",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.cp2"
},
{
"name": "nad",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.nad"
},
{
"name": "observable_values",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.observable_values"
},
{
"name": "run_summary",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.run_summary"
},
{
"name": "observable_labels",
"maps_to": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.observable_labels"
}
]
},
"title": "Luna2013_CircadianClock_SIRT1 Lab",
"models": [
{
"path": "models/core",
"alias": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model",
"parameters": {
"model_path": "data/MODEL2112310002.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model_observable_values"
],
"from": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.observable_values"
},
{
"to": [
"visualisation.metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model_run_summary"
],
"from": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.run_summary"
},
{
"to": [
"visualisation.metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model_observable_labels"
],
"from": "metabolism_sbml_luna2013_circadianclock_sirt1_model2112310002_model.observable_labels"
}
],
"package": "luna2013-circadianclock-sirt1",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "An in silico model to examine damage-induced circadian phase shifts by investigating a possible mechanism linking circadian rhythms to metabolism. The proposed model involves two DNA damage response p.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageluna2013-circadianclock-sirt1
Created2026-05-15
Updated2026-06-13
biomodels_ebifaithfulmetabolismodesbmltelluriumvisualisationother