Novak2004 - A Model for Restriction Point Control of the Mammalian Cell Cycle Lab

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Single-model lab wrapper for Novak2004 - A Model for Restriction Point Control of the Mammalian Cell Cycle. <notes xmlns='http://www.sbml.org/sbml/level2/version4'> <body xmlns='http://www.w3.org/1999/xhtml'> <pre>Inhibition of protein synthesis by cycloheximide blocks subsequent division. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.
Manifest
{
  "io": {
    "inputs": [
      {
        "name": "e2ft",
        "label": "E2FT",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.e2ft",
        "description": "Controls E2FT in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.e2ft`."
      },
      {
        "name": "pp1t",
        "label": "PP1T",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.pp1t",
        "description": "Controls PP1T in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.pp1t`."
      },
      {
        "name": "rb_t",
        "label": "Rb T",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.rb_t",
        "description": "Controls Rb T in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.rb_t`."
      },
      {
        "name": "cyclin_et",
        "label": "Cyclin ET",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_et",
        "description": "Controls Cyclin ET in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_et`."
      },
      {
        "name": "pp1a",
        "label": "PP1A",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.pp1a",
        "description": "Controls PP1A in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.pp1a`."
      },
      {
        "name": "rb_hypo",
        "label": "Rb Hypo",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.rb_hypo",
        "description": "Controls Rb Hypo in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.rb_hypo`."
      }
    ],
    "outputs": [
      {
        "name": "early_response_gene_module",
        "label": "Early response gene module",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.early_response_gene_module",
        "description": "Tracks Early response gene module in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.early_response_gene_module`."
      },
      {
        "name": "delayed_response_gene_module",
        "label": "Delayed response gene module",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.delayed_response_gene_module",
        "description": "Tracks Delayed response gene module in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.delayed_response_gene_module`."
      },
      {
        "name": "cyclin_d",
        "label": "Cyclin D",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_d",
        "description": "Tracks Cyclin D in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_d`."
      },
      {
        "name": "cyclin_d_kip1",
        "label": "Cyclin D:Kip1",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_d_kip1",
        "description": "Tracks Cyclin D:Kip1 in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_d_kip1`."
      },
      {
        "name": "cyclin_e",
        "label": "Cyclin E",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_e",
        "description": "Tracks Cyclin E in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_e`."
      },
      {
        "name": "cyclin_e_kip1",
        "label": "Cyclin E:Kip1",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_e_kip1",
        "description": "Tracks Cyclin E:Kip1 in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_e_kip1`."
      },
      {
        "name": "cyclin_a",
        "label": "Cyclin A",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_a",
        "description": "Tracks Cyclin A in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_a`."
      },
      {
        "name": "cyclin_a_kip1",
        "label": "Cyclin A:Kip1",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_a_kip1",
        "description": "Tracks Cyclin A:Kip1 in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_a_kip1`."
      },
      {
        "name": "kip1_cdk_inhibitor",
        "label": "Kip1 CDK inhibitor",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.kip1_cdk_inhibitor",
        "description": "Tracks Kip1 CDK inhibitor in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.kip1_cdk_inhibitor`."
      },
      {
        "name": "e2f_transcription_factor",
        "label": "E2F transcription factor",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.e2f_transcription_factor",
        "description": "Tracks E2F transcription factor in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.e2f_transcription_factor`."
      },
      {
        "name": "cyclin_b",
        "label": "Cyclin B",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_b",
        "description": "Tracks Cyclin B in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cyclin_b`."
      },
      {
        "name": "cdh1_apc_c_activator",
        "label": "Cdh1 APC/C activator",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdh1_apc_c_activator",
        "description": "Tracks Cdh1 APC/C activator in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdh1_apc_c_activator`."
      },
      {
        "name": "cdc20t",
        "label": "Cdc20T",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdc20t",
        "description": "Tracks Cdc20T in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdc20t`."
      },
      {
        "name": "cdc20_apc_c_activator",
        "label": "Cdc20 APC/C activator",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdc20_apc_c_activator",
        "description": "Tracks Cdc20 APC/C activator in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.cdc20_apc_c_activator`."
      },
      {
        "name": "ppx_phosphatase",
        "label": "PPX phosphatase",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.ppx_phosphatase",
        "description": "Tracks PPX phosphatase in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.ppx_phosphatase`."
      },
      {
        "name": "phosphorylated_ie",
        "label": "Phosphorylated IE",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.phosphorylated_ie",
        "description": "Tracks Phosphorylated IE in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.phosphorylated_ie`."
      },
      {
        "name": "model_state_gm",
        "label": "Model state GM",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.model_state_gm",
        "description": "Tracks Model state GM in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.model_state_gm`."
      },
      {
        "name": "mass",
        "label": "Mass",
        "maps_to": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.mass",
        "description": "Tracks Mass in the lab model via `cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.mass`."
      }
    ]
  },
  "title": "Novak2004 - A Model for Restriction Point Control of the Mammalian Cell Cycle Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model_state"
      ],
      "from": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.state"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model_summary"
      ],
      "from": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.summary"
    },
    {
      "to": [
        "visualisation.cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model_species_labels"
      ],
      "from": "cellcycle_sbml_novak2004_a_model_for_restriction_point_control_model2006080001_model.species_labels"
    }
  ],
  "package": "novak2004-restriction-point-control",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Single-model lab wrapper for Novak2004 - A Model for Restriction Point Control of the Mammalian Cell Cycle. &lt;notes xmlns='http://www.sbml.org/sbml/level2/version4'&gt; &lt;body xmlns='http://www.w3.org/1999/xhtml'&gt; &lt;pre&gt;Inhibition of protein synthesis by cycloheximide blocks subsequent division. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
  "schema_version": "2.0"
}
Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagenovak2004-restriction-point-control
Created2026-05-15
Updated2026-06-13
cellcyclesbmlbiomodels_ebifaithfulvisualisationother