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Koo et al. (2013) model of how laminar shear stress at the endothelial surface drives calcium influx and activates endothelial nitric oxide synthase (eNOS).
Manifest
{
"description": "Koo et al. (2013) model of how laminar shear stress at the endothelial surface drives calcium influx and activates endothelial nitric oxide synthase (eNOS).",
"io": {
"inputs": [
{
"maps_to": "koo2013_shear_stress_calcium_influx.integration_step",
"name": "integration_step"
},
{
"maps_to": "koo2013_shear_stress_calcium_influx.stimulus_intensity",
"name": "stimulus_intensity"
}
],
"outputs": [
{
"maps_to": "koo2013_shear_stress_calcium_influx.cytosolic_calcium",
"name": "cytosolic_calcium"
},
{
"maps_to": "koo2013_shear_stress_calcium_influx.ip3",
"name": "ip3"
},
{
"maps_to": "koo2013_shear_stress_calcium_influx.state",
"name": "state"
},
{
"maps_to": "koo2013_shear_stress_calcium_influx.summary",
"name": "summary"
}
]
},
"models": [
{
"alias": "koo2013_shear_stress_calcium_influx",
"parameters": {
"integration_step": 1,
"model_path": "data/BIOMD0000000464.xml"
},
"path": "models/core"
},
{
"alias": "visualisation",
"path": "models/visualisation"
}
],
"package": "koo2013-calcium-influx",
"runtime": {
"communication_step": 10,
"duration": 600,
"initial_inputs": {}
},
"schema_version": "2.0",
"title": "Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation Lab",
"version": "1.0.0",
"wiring": [
{
"from": "koo2013_shear_stress_calcium_influx.cytosolic_calcium",
"to": [
"visualisation.koo2013_shear_stress_calcium_influx_cytosolic_calcium"
]
},
{
"from": "koo2013_shear_stress_calcium_influx.ip3",
"to": [
"visualisation.koo2013_shear_stress_calcium_influx_ip3"
]
},
{
"from": "koo2013_shear_stress_calcium_influx.state",
"to": [
"visualisation.koo2013_shear_stress_calcium_influx_state"
]
},
{
"from": "koo2013_shear_stress_calcium_influx.summary",
"to": [
"visualisation.koo2013_shear_stress_calcium_influx_summary"
]
}
]
}Runtime
Duration600
Comms Step10
Runs
Total3
Completed3
Failed0
Metadata
Packagekoo2013-calcium-influx
Created2026-05-04
Updated2026-06-13
biomechanicsendothelialshear-stressmechanotransductioncalciumsbmlbiomodels_ebifaithfulvisualisationkoo2013other