BiosimulantBiosimulant
⌘K
Open Web Studio(opens in a new tab)

Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation Lab

About lab

One published Lab

Build with this Lab. Run it anywhere.

Use the same immutable release locally or through managed cloud execution, with its exact version and provenance preserved.

Preparing exact examples…

Koo et al. (2013) model of how laminar shear stress at the endothelial surface drives calcium influx and activates endothelial nitric oxide synthase (eNOS).

Manifest

{
  "description": "Koo et al. (2013) model of how laminar shear stress at the endothelial surface drives calcium influx and activates endothelial nitric oxide synthase (eNOS).",
  "io": {
    "inputs": [
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.integration_step",
        "name": "integration_step"
      },
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.stimulus_intensity",
        "name": "stimulus_intensity"
      }
    ],
    "outputs": [
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.cytosolic_calcium",
        "name": "cytosolic_calcium"
      },
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.ip3",
        "name": "ip3"
      },
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.state",
        "name": "state"
      },
      {
        "maps_to": "koo2013_shear_stress_calcium_influx.summary",
        "name": "summary"
      }
    ]
  },
  "models": [
    {
      "alias": "koo2013_shear_stress_calcium_influx",
      "parameters": {
        "integration_step": 1,
        "model_path": "data/BIOMD0000000464.xml"
      },
      "path": "models/core"
    },
    {
      "alias": "visualisation",
      "path": "models/visualisation"
    }
  ],
  "package": "koo2013-calcium-influx",
  "runtime": {
    "communication_step": 10,
    "duration": 600,
    "initial_inputs": {}
  },
  "schema_version": "2.0",
  "title": "Koo2013 Shear-Stress Induced Calcium Influx and eNOS Activation Lab",
  "version": "1.0.0",
  "wiring": [
    {
      "from": "koo2013_shear_stress_calcium_influx.cytosolic_calcium",
      "to": [
        "visualisation.koo2013_shear_stress_calcium_influx_cytosolic_calcium"
      ]
    },
    {
      "from": "koo2013_shear_stress_calcium_influx.ip3",
      "to": [
        "visualisation.koo2013_shear_stress_calcium_influx_ip3"
      ]
    },
    {
      "from": "koo2013_shear_stress_calcium_influx.state",
      "to": [
        "visualisation.koo2013_shear_stress_calcium_influx_state"
      ]
    },
    {
      "from": "koo2013_shear_stress_calcium_influx.summary",
      "to": [
        "visualisation.koo2013_shear_stress_calcium_influx_summary"
      ]
    }
  ]
}

Runtime

Duration600
Comms Step10

Runs

Total3
Completed3
Failed0

Metadata

Packagekoo2013-calcium-influx
Created2026-05-04
Updated2026-06-13
biomechanicsendothelialshear-stressmechanotransductioncalciumsbmlbiomodels_ebifaithfulvisualisationkoo2013other