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Mathematical model of blood coagulation investigating effects of varied factor VIIa on thrombin generation. It can be used to explore systemsbiology mitrophanov2011 mode of action of dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_m_i_ia_atiii",
"label": "Initial M I Ia Atiii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_m_i_ia_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa_ATIII`."
},
{
"name": "initial_m_i_ia",
"label": "Initial M I Ia",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_m_i_ia",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa`."
},
{
"name": "initial_xa_va_ii",
"label": "Initial Xa Va Ii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_xa_va_ii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va_II`."
},
{
"name": "initial_xa_va",
"label": "Initial Xa Va",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_xa_va",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va`."
},
{
"name": "initial_xa_tfpi",
"label": "Initial Xa Tfpi",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_xa_tfpi",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_TFPI`."
},
{
"name": "initial_xa_atiii",
"label": "Initial Xa Atiii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.initial_xa_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_ATIII`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.species_labels"
},
{
"name": "m_i_ia_atiii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.m_i_ia_atiii"
},
{
"name": "m_i_ia",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.m_i_ia"
},
{
"name": "xa_va_ii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.xa_va_ii"
},
{
"name": "xa_va",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.xa_va"
},
{
"name": "xa_tfpi",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.xa_tfpi"
},
{
"name": "xa_atiii",
"maps_to": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.xa_atiii"
}
]
},
"tags": [
"generegulation",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Mitrophanov2011 Mode Of Action Of Rfviia On Thrombin Generation Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model_state"
],
"from": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model_summary"
],
"from": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model_species_labels"
],
"from": "systemsbiology_sbml_mitrophanov2011_mode_of_action_of_rfviia_on_thro_model1806040001_model.species_labels"
}
],
"package": "mitrophanov2011-mode-of-action-of-rfviia-on-thrombin-generation",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.1",
"description": "Mathematical model of blood coagulation investigating effects of varied factor VIIa on thrombin generation. It can be used to explore systemsbiology mitrophanov2011 mode of action of dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagemitrophanov2011-mode-of-action-of-rfviia-on-thrombin-generation
Created2026-05-17
Updated2026-06-13
generegulationsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother