Walsh2014 - Inhibition kinetics of DAPT on APP Cleavage Lab

{
  "io": {
    "inputs": [
      {
        "name": "dapt_inhibitor_concentration",
        "label": "Dapt Inhibitor Concentration",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.dapt_inhibitor_concentration"
      },
      {
        "name": "substrate_concentration",
        "label": "Substrate Concentration",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.substrate_concentration"
      },
      {
        "name": "cleavage_state",
        "label": "Cleavage State",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.cleavage_state"
      },
      {
        "name": "cleavage_vmax_1",
        "label": "Cleavage VMAX 1",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.cleavage_vmax_1"
      },
      {
        "name": "cleavage_vmax_2",
        "label": "Cleavage VMAX 2",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.cleavage_vmax_2"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.species_labels"
      },
      {
        "name": "app_cleavage_state",
        "label": "APP Cleavage State",
        "maps_to": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.app_cleavage_state"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "neuroscience",
    "enzyme-inhibition",
    "amyloid",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "Walsh2014 - Inhibition kinetics of DAPT on APP Cleavage Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model",
      "parameters": {
        "model_path": "data/BIOMD0000000617.xml",
        "integration_step": 0.2
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model_state"
      ],
      "from": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model_summary"
      ],
      "from": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model_species_labels"
      ],
      "from": "pharmacology_sbml_walsh2014_inhibition_kinetics_of_dapt_on_app_cle_biomd0000000617_model.species_labels"
    }
  ],
  "package": "walsh2014-dapt-app-cleavage",
  "runtime": {
    "duration": 60,
    "initial_inputs": {},
    "communication_step": 2
  },
  "version": "1.0.0",
  "description": "Walsh2014 - Inhibition kinetics of DAPT onAPP Cleavage This model is described in the article: Are improper kinetic models hampering drug development? It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}