Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin Lab

{
  "io": {
    "inputs": [
      {
        "name": "dose_int2_source_parameter",
        "label": "Dose Int2 source parameter",
        "units": "native SBML value",
        "default": -2,
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.dose_int2_source_parameter",
        "description": "Dose Int2 source parameter. Maps to bundled SBML parameter `Dose_Int2`."
      },
      {
        "name": "dose_int1_source_parameter",
        "label": "Dose Int1 source parameter",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.dose_int1_source_parameter",
        "description": "Dose Int1 source parameter. Maps to bundled SBML parameter `Dose_Int1`."
      },
      {
        "name": "dose_source_parameter",
        "label": "Dose source parameter",
        "units": "native SBML value",
        "default": 5203.84,
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.dose_source_parameter",
        "description": "Dose source parameter. Maps to bundled SBML parameter `Dose`."
      },
      {
        "name": "initial_tumor_size",
        "label": "TumorSize",
        "units": "native SBML value",
        "default": 6.66,
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.initial_tumor_size",
        "description": "Initial TumorSize. Sets the initial value of bundled SBML symbol `TumorSize`."
      }
    ],
    "outputs": [
      {
        "name": "tumor_size",
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.tumor_size",
        "description": "TumorSize observable. Maps to SBML symbol `TumorSize`."
      },
      {
        "name": "ce",
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.ce",
        "description": "Ce observable. Maps to SBML symbol `Ce`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "chemotherapy",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Tham2008 - PDmodel, Tumour shrinkage by gemcitabine and carboplatin Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model_state"
      ],
      "from": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model_summary"
      ],
      "from": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model_species_labels"
      ],
      "from": "oncology_sbml_tham2008_pdmodel_tumour_shrinkage_by_gemcitabine_biomd0000000234_model.species_labels"
    }
  ],
  "package": "tham2008-pdmodel-tumour-shrinkage-by-gemcitabine-and-carboplatin",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "PURPOSE: This tumor response pharmacodynamic model aims to describe primary lesion shrinkage in non-small cell lung cancer over time and determine if concentration-based exposure metrics for gemcitabi. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}