Aguda1999 - Cell Cycle Restriction Point Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_a_cyclin_e_cdk2",
        "label": "Initial A Cyclin E Cdk2",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.initial_a_cyclin_e_cdk2",
        "description": "Initial value for A Cyclin E Cdk2. Maps to source symbol `a_CyclinE_Cdk2`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "dimensionless"
        ]
      },
      {
        "name": "initial_cyc_d_cdk4",
        "label": "Initial Cyc D Cdk4",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.initial_cyc_d_cdk4",
        "description": "Initial value for Cyc D Cdk4. Maps to source symbol `CycD_Cdk4`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name.",
        "accepted_units": [
          "dimensionless"
        ]
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Selected Source State",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation Summary",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.summary"
      },
      {
        "name": "trajectory",
        "label": "Source Trajectory",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.trajectory"
      },
      {
        "name": "variable_labels",
        "label": "Observable Labels",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.variable_labels"
      },
      {
        "name": "a_cyclin_e_cdk2",
        "label": "A Cyclin E Cdk2",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.a_cyclin_e_cdk2",
        "description": "A Cyclin E Cdk2. Maps to source symbol `a_CyclinE_Cdk2`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "cyc_d_cdk4",
        "label": "Cyc D Cdk4",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.cyc_d_cdk4",
        "description": "Cyc D Cdk4. Maps to source symbol `CycD_Cdk4`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "cyc_d_cdk4_p27",
        "label": "Cyc D Cdk4 P27",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.cyc_d_cdk4_p27",
        "description": "Cyc D Cdk4 P27. Maps to source symbol `CycD_Cdk4_p27`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "cyc_e_cdk2_p27",
        "label": "Cyc E Cdk2 P27",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.cyc_e_cdk2_p27",
        "description": "Cyc E Cdk2 P27. Maps to source symbol `CycE_Cdk2_p27`. Units: dimensionless. Naming evidence: source symbol, component, or units provide a direct public name."
      },
      {
        "name": "e2f_activity",
        "label": "E2F Activity",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.e2f_activity",
        "description": "E2F Activity. Maps to source symbol `E2F`. Units: dimensionless. Naming evidence: source symbol E2F is an established transcription-factor activity marker."
      },
      {
        "name": "model_state_p_rb",
        "label": "Model State P Rb (source pRB)",
        "maps_to": "physiology_cellml_aguda_tang_1999_agudatang1999_model.model_state_p_rb",
        "description": "Model State P Rb (source pRB). Maps to source symbol `pRB`. Units: dimensionless. Naming evidence: source symbol is dimensionless but lacks enough evidence for a biological label."
      }
    ]
  },
  "title": "Aguda1999 - Cell Cycle Restriction Point Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "physiology_cellml_aguda_tang_1999_agudatang1999_model",
      "parameters": {
        "model_path": "data/aguda_tang_1999.cellml",
        "integration_step": 0.01
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.physiology_cellml_aguda_tang_1999_agudatang1999_model_state"
      ],
      "from": "physiology_cellml_aguda_tang_1999_agudatang1999_model.state"
    },
    {
      "to": [
        "visualisation.physiology_cellml_aguda_tang_1999_agudatang1999_model_summary"
      ],
      "from": "physiology_cellml_aguda_tang_1999_agudatang1999_model.summary"
    },
    {
      "to": [
        "visualisation.physiology_cellml_aguda_tang_1999_agudatang1999_model_trajectory"
      ],
      "from": "physiology_cellml_aguda_tang_1999_agudatang1999_model.trajectory"
    },
    {
      "to": [
        "visualisation.physiology_cellml_aguda_tang_1999_agudatang1999_model_variable_labels"
      ],
      "from": "physiology_cellml_aguda_tang_1999_agudatang1999_model.variable_labels"
    }
  ],
  "package": "aguda1999-cell-cycle-restriction-point",
  "runtime": {
    "duration": 0.01,
    "settle_steps": 1,
    "initial_inputs": {},
    "communication_step": 0.01
  },
  "version": "1.0.0",
  "description": "Source-faithful physiology lab for Aguda, Tang, 1999. Public controls and outputs are mapped to real source symbols for cell-cycle dynamics.",
  "schema_version": "2.0"
}