Hu2019 - Modeling Pancreatic Cancer Dynamics with Immunotherapy Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_z_effector_cells",
        "label": "Z Effector Cells",
        "units": "native SBML value",
        "default": 190000000,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_z_effector_cells",
        "description": "Initial Z Effector Cells. Sets the initial value of bundled SBML symbol `z_Effector_Cells`."
      },
      {
        "name": "initial_x_pcc",
        "label": "X PCC",
        "units": "native SBML value",
        "default": 1000000000,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_x_pcc",
        "description": "Initial X PCC. Sets the initial value of bundled SBML symbol `x_PCC`."
      },
      {
        "name": "initial_y_psc",
        "label": "Y PSC",
        "units": "native SBML value",
        "default": 5600000,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_y_psc",
        "description": "Initial Y PSC. Sets the initial value of bundled SBML symbol `y_PSC`."
      },
      {
        "name": "initial_w_tpc",
        "label": "W TPC",
        "units": "native SBML value",
        "default": 50000,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_w_tpc",
        "description": "Initial W TPC. Sets the initial value of bundled SBML symbol `w_TPC`."
      },
      {
        "name": "initial_v_tsc",
        "label": "V TSC",
        "units": "native SBML value",
        "default": 9.4,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_v_tsc",
        "description": "Initial V TSC. Sets the initial value of bundled SBML symbol `v_TSC`."
      },
      {
        "name": "initial_r_si_rna",
        "label": "R siRNA",
        "units": "native SBML value",
        "default": 1,
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.initial_r_si_rna",
        "description": "Initial R siRNA. Sets the initial value of bundled SBML symbol `R_siRNA`."
      }
    ],
    "outputs": [
      {
        "name": "z_effector_cells",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.z_effector_cells",
        "description": "Z Effector Cells observable. Maps to SBML symbol `z_Effector_Cells`."
      },
      {
        "name": "x_pcc",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.x_pcc",
        "description": "X PCC observable. Maps to SBML symbol `x_PCC`."
      },
      {
        "name": "y_psc",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.y_psc",
        "description": "Y PSC observable. Maps to SBML symbol `y_PSC`."
      },
      {
        "name": "w_tpc",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.w_tpc",
        "description": "W TPC observable. Maps to SBML symbol `w_TPC`."
      },
      {
        "name": "v_tsc",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.v_tsc",
        "description": "V TSC observable. Maps to SBML symbol `v_TSC`."
      },
      {
        "name": "r_si_rna",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.r_si_rna",
        "description": "R siRNA observable. Maps to SBML symbol `R_siRNA`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "immunology",
    "immunotherapy",
    "microenvironment",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Hu2019 - Modeling Pancreatic Cancer Dynamics with Immunotherapy Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model_state"
      ],
      "from": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model_summary"
      ],
      "from": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model_species_labels"
      ],
      "from": "oncology_sbml_hu2019_modeling_pancreatic_cancer_dynamics_with_biomd0000000792_model.species_labels"
    }
  ],
  "package": "hu2019-modeling-pancreatic-cancer-dynamics-with-immunotherapy",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "This is a mathematical model of pancreatic cancer that includes descriptions of pancreatic cancer cells, pancreatic stellate cells, effector cells and tumor-promoting and tumor-suppressing cytokines t. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}