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Its a mathematical model depicting CML (chronic myelogenous leukemia) interaction with T cells and impact of T cell activations on CML progression over time. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor_cells",
"label": "Tumor cells",
"units": "native SBML value",
"default": 10000,
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.initial_tumor_cells",
"description": "Initial Tumor cells. Sets the initial value of bundled SBML symbol `tumor_cells`."
},
{
"name": "initial_naive_t_cells",
"label": "Naive Tcells",
"units": "native SBML value",
"default": 1510,
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.initial_naive_t_cells",
"description": "Initial Naive Tcells. Sets the initial value of bundled SBML symbol `naive_Tcells`."
},
{
"name": "initial_eff_t_cells",
"label": "Eff Tcells",
"units": "native SBML value",
"default": 20,
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.initial_eff_t_cells",
"description": "Initial Eff Tcells. Sets the initial value of bundled SBML symbol `eff_Tcells`."
}
],
"outputs": [
{
"name": "tumor_cells",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.tumor_cells",
"description": "Tumor cells observable. Maps to SBML symbol `tumor_cells`."
},
{
"name": "naive_t_cells",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.naive_t_cells",
"description": "Naive Tcells observable. Maps to SBML symbol `naive_Tcells`."
},
{
"name": "eff_t_cells",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.eff_t_cells",
"description": "Eff Tcells observable. Maps to SBML symbol `eff_Tcells`."
},
{
"name": "state",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"curated",
"drug-response",
"faithful",
"immunology",
"immunotherapy",
"microenvironment",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Moore_2004_Mathematical model for CML and T cell interaction Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model_state"
],
"from": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.state"
},
{
"to": [
"visualisation.oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model_summary"
],
"from": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model_species_labels"
],
"from": "oncology_sbml_moore_2004_mathematical_model_for_cml_and_t_cell_biomd0000000733_model.species_labels"
}
],
"package": "moore-2004-mathematical-for-cml-and-t-cell-interaction",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Its a mathematical model depicting CML (chronic myelogenous leukemia) interaction with T cells and impact of T cell activations on CML progression over time. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagemoore-2004-mathematical-for-cml-and-t-cell-interaction
Created2026-05-16
Updated2026-06-13
biomodels_ebicurateddrug-responsefaithfulimmunologyimmunotherapymicroenvironmentoncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother