DoldánMartelli2013 - A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies Lab

{
  "io": {
    "inputs": [
      {
        "name": "ligand_concentration",
        "label": "Ligand Concentration",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.ligand_concentration"
      },
      {
        "name": "target_1_association_rate",
        "label": "Target 1 Association Rate",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_1_association_rate"
      },
      {
        "name": "target_1_dissociation_rate",
        "label": "Target 1 Dissociation Rate",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_1_dissociation_rate"
      },
      {
        "name": "target_2_association_rate",
        "label": "Target 2 Association Rate",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_2_association_rate"
      },
      {
        "name": "target_2_dissociation_rate",
        "label": "Target 2 Dissociation Rate",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_2_dissociation_rate"
      }
    ],
    "outputs": [
      {
        "name": "state",
        "label": "Tracked source state",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.species_labels"
      },
      {
        "name": "target_1_drug_complex",
        "label": "Target 1 Drug Complex",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_1_drug_complex"
      },
      {
        "name": "target_2_drug_complex",
        "label": "Target 2 Drug Complex",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_2_drug_complex"
      },
      {
        "name": "target_1_drug_effector_complex",
        "label": "Target 1 Drug Effector Complex",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_1_drug_effector_complex"
      },
      {
        "name": "target_2_drug_effector_complex",
        "label": "Target 2 Drug Effector Complex",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.target_2_drug_effector_complex"
      },
      {
        "name": "selectivity_complex_1",
        "label": "Selectivity Complex 1",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.selectivity_complex_1"
      },
      {
        "name": "selectivity_complex_2",
        "label": "Selectivity Complex 2",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.selectivity_complex_2"
      },
      {
        "name": "selectivity_complex_3",
        "label": "Selectivity Complex 3",
        "maps_to": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.selectivity_complex_3"
      }
    ]
  },
  "tags": [
    "pharmacology",
    "drug-discovery",
    "receptor-binding",
    "systems-biology",
    "sbml",
    "tellurium",
    "faithful",
    "biomodels_ebi"
  ],
  "title": "DoldánMartelli2013 - A Mathematical Model for the Rational Design of Chimeric Ligands in Selective Drug Therapies Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model",
      "parameters": {
        "model_path": "data/MODEL1907310001.xml",
        "integration_step": 0.2
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model_state"
      ],
      "from": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.state"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model_summary"
      ],
      "from": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.summary"
    },
    {
      "to": [
        "visualisation.pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model_species_labels"
      ],
      "from": "pharmacology_sbml_dold_nmartelli2013_a_mathematical_model_for_the_model1907310001_model.species_labels"
    }
  ],
  "package": "doldanmartelli2013-chimeric-ligands",
  "runtime": {
    "duration": 60,
    "initial_inputs": {},
    "communication_step": 2
  },
  "version": "1.0.0",
  "description": "This model attempts to provide a mathematical framework for describing the dynamics of receptor-drug complex formation of chimeric drugs. It can be used to explore dose-response dynamics and compare treatment scenarios across conditions.",
  "schema_version": "2.0"
}