Zeilfelder2025 - Model for human liver cancer cell line HepG2 Lab

{
  "io": {
    "inputs": [
      {
        "name": "input_il6_source_parameter",
        "label": "Input il6 source parameter",
        "units": "native SBML value",
        "default": 10,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.input_il6_source_parameter",
        "description": "Input il6 source parameter. Maps to bundled SBML parameter `input_il6`."
      },
      {
        "name": "il6_basal_source_parameter",
        "label": "Il6 basal source parameter",
        "units": "native SBML value",
        "default": 0.00957067090828757,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.il6_basal_source_parameter",
        "description": "Il6 basal source parameter. Maps to bundled SBML parameter `il6_basal`."
      },
      {
        "name": "il6_act_source_parameter",
        "label": "Il6 act source parameter",
        "units": "native SBML value",
        "default": 0.0226985677410744,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.il6_act_source_parameter",
        "description": "Il6 act source parameter. Maps to bundled SBML parameter `il6_act`."
      },
      {
        "name": "dcf_il6_basal_source_parameter",
        "label": "Dcf il6 basal source parameter",
        "units": "native SBML value",
        "default": 0.835096746625705,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.dcf_il6_basal_source_parameter",
        "description": "Dcf il6 basal source parameter. Maps to bundled SBML parameter `dcf_il6_basal`."
      },
      {
        "name": "initial_unphosphorylated_stat3",
        "label": "Unphosphorylated STAT3",
        "units": "native SBML value",
        "default": 1237.76392668883,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.initial_unphosphorylated_stat3",
        "description": "Initial Unphosphorylated STAT3. Sets the initial value of bundled SBML symbol `STAT3`."
      },
      {
        "name": "initial_active_cytoplasmic_stat3",
        "label": "Active cytoplasmic STAT3",
        "units": "native SBML value",
        "default": 24.1373740148803,
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.initial_active_cytoplasmic_stat3",
        "description": "Initial Active cytoplasmic STAT3. Sets the initial value of bundled SBML symbol `cpSTAT3`."
      }
    ],
    "outputs": [
      {
        "name": "unphosphorylated_stat3",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.unphosphorylated_stat3",
        "description": "Unphosphorylated STAT3 observable. Maps to SBML symbol `STAT3`."
      },
      {
        "name": "active_cytoplasmic_stat3",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.active_cytoplasmic_stat3",
        "description": "Active cytoplasmic STAT3 observable. Maps to SBML symbol `cpSTAT3`."
      },
      {
        "name": "active_nuclear_stat3",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.active_nuclear_stat3",
        "description": "Active nuclear STAT3 observable. Maps to SBML symbol `npSTAT3`."
      },
      {
        "name": "total_bmp_receptor",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.total_bmp_receptor",
        "description": "Total BMP receptor observable. Maps to SBML symbol `BMPR`."
      },
      {
        "name": "cofactor_activated_by_bmp_receptor",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.cofactor_activated_by_bmp_receptor",
        "description": "Cofactor activated by BMP receptor observable. Maps to SBML symbol `BMPR_delay1`."
      },
      {
        "name": "cofactor_activated_by_bmp_receptor_2",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.cofactor_activated_by_bmp_receptor_2",
        "description": "Cofactor activated by BMP receptor 2 observable. Maps to SBML symbol `BMPR_delay2`."
      },
      {
        "name": "state",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.state",
        "description": "Full raw SBML observable record for reproducibility and downstream visualisation."
      },
      {
        "name": "summary",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.summary",
        "description": "Change and peak summary across the simulated SBML observables."
      },
      {
        "name": "species_labels",
        "maps_to": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.species_labels",
        "description": "Mapping from selected raw SBML observable symbols to display labels."
      }
    ]
  },
  "tags": [
    "biomodels_ebi",
    "curated",
    "drug-response",
    "faithful",
    "oncology",
    "pharmacology",
    "physiology",
    "sbml",
    "signal-transduction",
    "signaling",
    "systemsbiology",
    "tumor-growth"
  ],
  "title": "Zeilfelder2025 - Model for human liver cancer cell line HepG2 Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model_state"
      ],
      "from": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.state"
    },
    {
      "to": [
        "visualisation.oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model_summary"
      ],
      "from": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.summary"
    },
    {
      "to": [
        "visualisation.oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model_species_labels"
      ],
      "from": "oncology_sbml_zeilfelder2025_model_for_human_liver_cancer_cell_model2503270001_model.species_labels"
    }
  ],
  "package": "zeilfelder2025-for-human-liver-cancer-cell-line-hepg2",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Mathematical multi-compartment model described by sets of coupledordinary differential equations (ODEs) for studying the IL6 and SMAD signaling in HepG2 human cancer cell lines. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
  "schema_version": "2.0"
}