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Role of vascular normalization in benefit from metronomic chemotherapy.Mpekris F1, Baish JW2, Stylianopoulos T3, Jain RK4.Author informationAbstractMetronomic dosing of chemotherapy-defined as frequen. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_csc",
"label": "Csc",
"units": "native SBML value",
"default": 1,
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.initial_csc",
"description": "Initial Csc. Sets the initial value of bundled SBML symbol `Csc`."
}
],
"outputs": [
{
"name": "chemotherapy_level",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.chemotherapy_level",
"description": "C observable. Maps to SBML symbol `C`."
},
{
"name": "tumor_cells",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.tumor_cells",
"description": "T observable. Maps to SBML symbol `T`."
},
{
"name": "csc",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.csc",
"description": "Csc observable. Maps to SBML symbol `Csc`."
},
{
"name": "infected_tumor_cells",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.infected_tumor_cells",
"description": "I observable. Maps to SBML symbol `I`."
},
{
"name": "normal_cells",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.normal_cells",
"description": "N observable. Maps to SBML symbol `N`."
},
{
"name": "l",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.l",
"description": "L observable. Maps to SBML symbol `L`."
},
{
"name": "state",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"angiogenesis",
"biomodels_ebi",
"chemotherapy",
"curated",
"drug-response",
"faithful",
"microenvironment",
"oncology",
"pharmacology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Mpekris2017 - Role of vascular normalization in benefit from metronomic chemotherapy Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model_state"
],
"from": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.state"
},
{
"to": [
"visualisation.oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model_summary"
],
"from": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model_species_labels"
],
"from": "oncology_sbml_mpekris2017_role_of_vascular_normalization_in_be_model2001200002_model.species_labels"
}
],
"package": "mpekris2017-role-of-vascular-normalization-in-benefit-f-975ac2e9",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Role of vascular normalization in benefit from metronomic chemotherapy.Mpekris F1, Baish JW2, Stylianopoulos T3, Jain RK4.Author informationAbstractMetronomic dosing of chemotherapy-defined as frequen. It can be used to explore tumor-related dynamics and compare treatment-response behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagempekris2017-role-of-vascular-normalization-in-benefit-f-975ac2e9
Created2026-05-16
Updated2026-06-13
angiogenesisbiomodels_ebichemotherapycurateddrug-responsefaithfulmicroenvironmentoncologypharmacologyphysiologysbmlsystemsbiologytumor-growthvisualisationother