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This is a COPASI version of the HIV/HPV coinfection model submitted to PLoS One.Title: Modeling the mechanisms by which HIV-associated immunosuppression influences HPV persistence at the oral mucosaAu. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_infection_observable_1",
"label": "Initial Unresolved Infection Observable 1",
"units": "native source value",
"default": 48000,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.initial_unresolved_infection_observable_1",
"description": "Initial Unresolved Infection Observable 1. Sets the initial value of bundled SBML species `s2`."
},
{
"name": "initial_unresolved_infection_observable_2",
"label": "Initial Unresolved Infection Observable 2",
"units": "native source value",
"default": 2364.02569593148,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.initial_unresolved_infection_observable_2",
"description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `s3`."
},
{
"name": "initial_unresolved_infection_observable_3",
"label": "Initial Unresolved Infection Observable 3",
"units": "native source value",
"default": 250000,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.initial_unresolved_infection_observable_3",
"description": "Initial Unresolved Infection Observable 3. Sets the initial value of bundled SBML species `s4`."
},
{
"name": "initial_unresolved_infection_observable_4",
"label": "Initial Unresolved Infection Observable 4",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.initial_unresolved_infection_observable_4",
"description": "Initial Unresolved Infection Observable 4. Sets the initial value of bundled SBML species `s14`."
},
{
"name": "initial_unresolved_infection_observable_5",
"label": "Initial Unresolved Infection Observable 5",
"units": "native source value",
"default": 0.01,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.initial_unresolved_infection_observable_5",
"description": "Initial Unresolved Infection Observable 5. Sets the initial value of bundled SBML species `s16`."
},
{
"name": "decay_of_t_cells_rate",
"label": "Decay Of T Cells Rate",
"units": "native source value",
"default": 0.01,
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.decay_of_t_cells_rate",
"description": "Decay Of T Cells Rate. Sets bundled SBML parameter `d`."
}
],
"outputs": [
{
"name": "unresolved_infection_observable_1",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.unresolved_infection_observable_1"
},
{
"name": "unresolved_infection_observable_2",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.unresolved_infection_observable_2"
},
{
"name": "unresolved_infection_observable_3",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.unresolved_infection_observable_3"
},
{
"name": "unresolved_infection_observable_4",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.unresolved_infection_observable_4"
},
{
"name": "unresolved_infection_observable_5",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.unresolved_infection_observable_5"
},
{
"name": "state",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.species_labels"
}
]
},
"title": "Verma2016 - HIV and HPV co-infection, T-cell response Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model_state"
],
"from": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.state"
},
{
"to": [
"visualisation.immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model_summary"
],
"from": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model_species_labels"
],
"from": "immunology_sbml_verma2016_hiv_and_hpv_co_infection_t_cell_respon_biomd0000000872_model.species_labels"
}
],
"package": "verma2016-hiv-and-hpv-co-infection-t-cell",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a COPASI version of the HIV/HPV coinfection model submitted to PLoS One.Title: Modeling the mechanisms by which HIV-associated immunosuppression influences HPV persistence at the oral mucosaAu. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageverma2016-hiv-and-hpv-co-infection-t-cell
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother