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Reused mathematical model (Hockin et al., 2002) of blood coagulation simulating the effects of coagulation factor inhibitors, fondaparinux (synthetic heparin) and Rivaroxaban. It can be used to explore systemsbiology orfeo2010 simulating the effects of dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_m_i_ia_atiii",
"label": "Initial M I Ia Atiii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_m_i_ia_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa_ATIII`."
},
{
"name": "initial_m_i_ia",
"label": "Initial M I Ia",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_m_i_ia",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `mIIa`."
},
{
"name": "initial_xa_va_ii",
"label": "Initial Xa Va Ii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_xa_va_ii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va_II`."
},
{
"name": "initial_xa_va",
"label": "Initial Xa Va",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_xa_va",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_Va`."
},
{
"name": "initial_xa_tfpi",
"label": "Initial Xa Tfpi",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_xa_tfpi",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_TFPI`."
},
{
"name": "initial_xa_atiii",
"label": "Initial Xa Atiii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.initial_xa_atiii",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Xa_ATIII`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.species_labels"
},
{
"name": "m_i_ia_atiii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.m_i_ia_atiii"
},
{
"name": "m_i_ia",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.m_i_ia"
},
{
"name": "xa_va_ii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.xa_va_ii"
},
{
"name": "xa_va",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.xa_va"
},
{
"name": "xa_tfpi",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.xa_tfpi"
},
{
"name": "xa_atiii",
"maps_to": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.xa_atiii"
}
]
},
"tags": [
"generegulation",
"pharmacology",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Orfeo2010 Simulating The Effects Of Fondaparinux And Rivaroxaban On Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model_state"
],
"from": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model_summary"
],
"from": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model_species_labels"
],
"from": "systemsbiology_sbml_orfeo2010_simulating_the_effects_of_fondaparinux_model1807240001_model.species_labels"
}
],
"package": "orfeo2010-simulating-the-effects-of-fondaparinux-and-ri-2e8a0d3f",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Reused mathematical model (Hockin et al., 2002) of blood coagulation simulating the effects of coagulation factor inhibitors, fondaparinux (synthetic heparin) and Rivaroxaban. It can be used to explore systemsbiology orfeo2010 simulating the effects of dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageorfeo2010-simulating-the-effects-of-fondaparinux-and-ri-2e8a0d3f
Created2026-05-17
Updated2026-06-13
generegulationpharmacologysystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother