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This is the model described in the article: A bistable Rb-E2F switch underlies the restriction point Guang Yao, Tae Jun Lee, Seiichi Mori, Joseph R. It can be used to explore systemsbiology yao2008 rb e2f switch BioModels0000000318 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_rb_e2_f_complex",
"label": "Initial Rb E2 F Complex",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_rb_e2_f_complex",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RE`."
},
{
"name": "initial_phosphorylated_rb",
"label": "Initial Phosphorylated Rb",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_phosphorylated_rb",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RP`."
},
{
"name": "initial_model_state_rb",
"label": "Initial Model State Rb",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_model_state_rb",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `RB`."
},
{
"name": "initial_model_state_myc",
"label": "Initial Model State Myc",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_model_state_myc",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `MC`."
},
{
"name": "initial_e2_f",
"label": "Initial E2 F",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_e2_f",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `EF`."
},
{
"name": "initial_cyc_e",
"label": "Initial Cyc E",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.initial_cyc_e",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `CE`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.species_labels"
},
{
"name": "rb_e2_f_complex",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.rb_e2_f_complex"
},
{
"name": "phosphorylated_rb",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.phosphorylated_rb"
},
{
"name": "model_state_rb",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.model_state_rb"
},
{
"name": "myc",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.myc"
},
{
"name": "e2_f",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.e2_f"
},
{
"name": "cyc_e",
"maps_to": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.cyc_e"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Yao2008 Rb E2f Switch Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model_state"
],
"from": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model_summary"
],
"from": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model_species_labels"
],
"from": "systemsbiology_sbml_yao2008_rb_e2f_switch_biomd0000000318_model.species_labels"
}
],
"package": "yao2008-rb-e2f-switch",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This is the model described in the article: A bistable Rb-E2F switch underlies the restriction point Guang Yao, Tae Jun Lee, Seiichi Mori, Joseph R. It can be used to explore systemsbiology yao2008 rb e2f switch BioModels0000000318 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageyao2008-rb-e2f-switch
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother