Passos2010 Dnadamage Cellularsenescence Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_p53_mrna",
        "label": "Initial P53 MRNA",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_p53_mrna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p53_mRNA`."
      },
      {
        "name": "initial_mdm2_mrna",
        "label": "Initial Mdm2 MRNA",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_mdm2_mrna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Mdm2_mRNA`."
      },
      {
        "name": "initial_p21_mrna",
        "label": "Initial P21 MRNA",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_p21_mrna",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p21_mRNA`."
      },
      {
        "name": "initial_atmi",
        "label": "Initial Atmi",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_atmi",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `ATMI`."
      },
      {
        "name": "initial_model_state_p38",
        "label": "Initial Model State P38",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_model_state_p38",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `p38`."
      },
      {
        "name": "initial_mdm2_p53",
        "label": "Initial Mdm2 P53",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.initial_mdm2_p53",
        "description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Mdm2_p53`."
      }
    ],
    "outputs": [
      {
        "name": "state",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.state"
      },
      {
        "name": "summary",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.summary"
      },
      {
        "name": "species_labels",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.species_labels"
      },
      {
        "name": "p53_mrna",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.p53_mrna"
      },
      {
        "name": "mdm2_mrna",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.mdm2_mrna"
      },
      {
        "name": "p21_mrna",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.p21_mrna"
      },
      {
        "name": "atmi",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.atmi"
      },
      {
        "name": "p38",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.p38"
      },
      {
        "name": "mdm2_p53",
        "maps_to": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.mdm2_p53"
      }
    ]
  },
  "tags": [
    "systemsbiology",
    "sbml",
    "biomodels_ebi",
    "faithful",
    "curated"
  ],
  "title": "Passos2010 Dnadamage Cellularsenescence Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model_state"
      ],
      "from": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.state"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model_summary"
      ],
      "from": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.summary"
    },
    {
      "to": [
        "visualisation.systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model_species_labels"
      ],
      "from": "systemsbiology_sbml_passos2010_dnadamage_cellularsenescence_biomd0000000287_model.species_labels"
    }
  ],
  "package": "passos2010-dnadamage-cellularsenescence",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "This is the model described in: Feedback between p21 and reactive oxygen production is necessary for cell senescence. Passos JF, Nelson G, Wang C, Richter T, Simillion C, Proctor CJ, Miwa S, Olijslage.",
  "schema_version": "2.0"
}