Sluka2016 - Acetaminophen metabolism Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_drug_metabolism_state_1",
        "units": "native SBML value",
        "default": 0.1,
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.initial_drug_metabolism_state_1",
        "description": "Initial condition for drug metabolism state 1. Maps to bundled SBML symbol `APAP`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_2",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.initial_drug_metabolism_state_2",
        "description": "Initial condition for drug metabolism state 2. Maps to bundled SBML symbol `NAPQI`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_glutathione",
        "units": "native SBML value",
        "default": 10,
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.initial_glutathione",
        "description": "Initial condition for glutathione. Maps to bundled SBML symbol `GSH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_4",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.initial_drug_metabolism_state_4",
        "description": "Initial condition for drug metabolism state 4. Maps to bundled SBML symbol `NAPQIGSH`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      },
      {
        "name": "initial_drug_metabolism_state_5",
        "units": "native SBML value",
        "default": 0,
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.initial_drug_metabolism_state_5",
        "description": "Initial condition for drug metabolism state 5. Maps to bundled SBML symbol `APAPconj_Glu`. Applied before the Tellurium simulation starts; this does not change kinetic parameters or equations. Default from bundled SBML initial value."
      }
    ],
    "outputs": [
      {
        "name": "drug_metabolism_state_1",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.drug_metabolism_state_1"
      },
      {
        "name": "drug_metabolism_state_2",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.drug_metabolism_state_2"
      },
      {
        "name": "glutathione",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.glutathione"
      },
      {
        "name": "drug_metabolism_state_4",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.drug_metabolism_state_4"
      },
      {
        "name": "drug_metabolism_state_5",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.drug_metabolism_state_5"
      },
      {
        "name": "observable_values",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.observable_values"
      },
      {
        "name": "run_summary",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.run_summary"
      },
      {
        "name": "observable_labels",
        "maps_to": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.observable_labels"
      }
    ]
  },
  "title": "Sluka2016 - Acetaminophen metabolism Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model",
      "parameters": {
        "model_path": "data/BIOMD0000000624.xml",
        "integration_step": 0.1
      }
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model_observable_values"
      ],
      "from": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.observable_values"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model_run_summary"
      ],
      "from": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.run_summary"
    },
    {
      "to": [
        "visualisation.metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model_observable_labels"
      ],
      "from": "metabolism_sbml_sluka2016_acetaminophen_metabolism_biomd0000000624_model.observable_labels"
    }
  ],
  "package": "sluka2016-acetaminophen-metabolism",
  "runtime": {
    "duration": 10,
    "initial_inputs": {},
    "communication_step": 1
  },
  "version": "1.0.0",
  "description": "Sluka2016 - Acetaminophen metabolism Liver metabolism of Acetaminophen: Acetaminophen (APAP) ismetabolized in the liver in both Phase I and Phase II reactions.Phase II reactions convert APAP to APAP-g. It can be used to explore metabolic flux dynamics and compare pathway behavior across conditions.",
  "schema_version": "2.0"
}