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Single-model lab wrapper for DeBoeck2021 - Modular approach to modeling the cell cycle, 5 ODE model with 3 bistable switches. Model of the mammalian cell cycle as a chain of bistable switches. There are three bistable responses: response of E2F to Cyclin D, of Cdk1 to Cyclin B and of APC/C to Cdk1 activity.
Manifest
{
"io": {
"inputs": [],
"outputs": [
{
"name": "cyclin_d",
"label": "Cyclin D",
"maps_to": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.cyclin_d",
"description": "Tracks Cyclin D in the lab model via `cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.cyclin_d`."
},
{
"name": "cyclin_b",
"label": "Cyclin B",
"maps_to": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.cyclin_b",
"description": "Tracks Cyclin B in the lab model via `cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.cyclin_b`."
}
]
},
"title": "DeBoeck2021 - Modular approach to modeling the cell cycle, 5 ODE model with 3 bistable switches Lab",
"models": [
{
"path": "models/core",
"alias": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model_state"
],
"from": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.state"
},
{
"to": [
"visualisation.cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model_summary"
],
"from": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.summary"
},
{
"to": [
"visualisation.cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model_species_labels"
],
"from": "cellcycle_sbml_deboeck2021_modular_approach_to_modeling_the_cel_biomd0000001080_model.species_labels"
}
],
"package": "deboeck2021-bistable-switches",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Single-model lab wrapper for DeBoeck2021 - Modular approach to modeling the cell cycle, 5 ODE model with 3 bistable switches. Model of the mammalian cell cycle as a chain of bistable switches. There are three bistable responses: response of E2F to Cyclin D, of Cdk1 to Cyclin B and of APC/C to Cdk1 activity.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagedeboeck2021-bistable-switches
Created2026-05-15
Updated2026-06-13
cellcyclesbmlbiomodels_ebifaithfulvisualisationother