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Two-model lab for Guyton1972 Pulmonary Oxygen Intake: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "integration_step",
"maps_to": "guyton1972_pulmonary_oxygen_intake_core.integration_step"
},
{
"name": "parameter_overrides",
"maps_to": "guyton1972_pulmonary_oxygen_intake_core.parameter_overrides"
},
{
"name": "initial_conditions",
"maps_to": "guyton1972_pulmonary_oxygen_intake_core.initial_conditions"
}
],
"outputs": [
{
"name": "scenario_metadata",
"maps_to": "guyton1972_pulmonary_oxygen_intake_scenario.scenario_metadata"
},
{
"name": "state",
"maps_to": "guyton1972_pulmonary_oxygen_intake_core.state"
},
{
"name": "run_summary",
"maps_to": "guyton1972_pulmonary_oxygen_intake_viz.run_summary"
}
]
},
"title": "Guyton1972 Pulmonary Oxygen Intake Lab",
"models": [
{
"path": "models/scenario",
"alias": "guyton1972_pulmonary_oxygen_intake_scenario",
"parameters": {
"schedule": {
"oxygen_demand": {
"unit": "dimensionless",
"label": "oxygen demand",
"active": true,
"baseline": 56.8057,
"recovery": 56.8057,
"challenge": 28.40285,
"description": "Scenario-controlled oxygen demand value."
},
"ambient_oxygen": {
"unit": "dimensionless",
"label": "ambient oxygen",
"active": false,
"baseline": 150,
"recovery": 150,
"challenge": 150,
"description": "Scenario-controlled ambient oxygen value."
},
"pulmonary_blood_flow": {
"unit": "dimensionless",
"label": "pulmonary blood flow",
"active": false,
"baseline": 4.97838,
"recovery": 4.97838,
"challenge": 4.97838,
"description": "Scenario-controlled pulmonary blood flow value."
}
},
"scenario_name": "Oxygen availability challenge",
"baseline_until": 150,
"challenge_until": 450,
"scenario_description": "Baseline is followed by a oxygen demand challenge and recovery period."
}
},
{
"path": "./models/core",
"alias": "guyton1972_pulmonary_oxygen_intake_core",
"parameters": {
"model_path": "data/MODEL0911047946.xml",
"integration_step": 1
}
},
{
"path": "./models/viz",
"alias": "guyton1972_pulmonary_oxygen_intake_viz",
"parameters": {
"lab_title": "Guyton1972 Pulmonary Oxygen Intake",
"lab_question": "Is pulmonary oxygen uptake sufficient?",
"integration_step": 1
}
}
],
"wiring": [
{
"to": [
"guyton1972_pulmonary_oxygen_intake_core.pulmonary_blood_flow"
],
"from": "guyton1972_pulmonary_oxygen_intake_scenario.pulmonary_blood_flow"
},
{
"to": [
"guyton1972_pulmonary_oxygen_intake_core.oxygen_demand"
],
"from": "guyton1972_pulmonary_oxygen_intake_scenario.oxygen_demand"
},
{
"to": [
"guyton1972_pulmonary_oxygen_intake_core.ambient_oxygen"
],
"from": "guyton1972_pulmonary_oxygen_intake_scenario.ambient_oxygen"
},
{
"to": [
"guyton1972_pulmonary_oxygen_intake_viz.scenario_metadata"
],
"from": "guyton1972_pulmonary_oxygen_intake_scenario.scenario_metadata"
},
{
"to": [
"guyton1972_pulmonary_oxygen_intake_viz.state"
],
"from": "guyton1972_pulmonary_oxygen_intake_core.state"
},
{
"to": [
"guyton1972_pulmonary_oxygen_intake_viz.species_labels"
],
"from": "guyton1972_pulmonary_oxygen_intake_core.species_labels"
}
],
"package": "guyton1972-pulmonary-oxygen-intake",
"runtime": {
"duration": 600,
"initial_inputs": {
"guyton1972_pulmonary_oxygen_intake_core": {
"integration_step": 1,
"initial_conditions": {
"payload": {}
},
"parameter_overrides": {
"payload": {}
}
}
},
"communication_step": 1
},
"version": "1.0.0",
"description": "Two-model lab for Guyton1972 Pulmonary Oxygen Intake: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
"schema_version": "2.0"
}Runtime
Duration600
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageguyton1972-pulmonary-oxygen-intake
Created2026-05-14
Updated2026-06-13
cardiovascularscenariostimulussbmlbiomodels_ebifaithfulvisualizationother