Zeilfelder2025 - Model for primary human hepatocytes (PHH) Lab

{
  "io": {
    "inputs": [
      {
        "name": "initial_input_apap_level",
        "label": "Input Apap",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.initial_input_apap_level",
        "description": "Input Apap source parameter. Maps to SBML symbol `input_apap` and preserves the bundled default."
      },
      {
        "name": "initial_input_cyclo_level",
        "label": "Input Cyclo",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.initial_input_cyclo_level",
        "description": "Input Cyclo source parameter. Maps to SBML symbol `input_cyclo` and preserves the bundled default."
      },
      {
        "name": "initial_input_dcf_level",
        "label": "Input Dcf",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.initial_input_dcf_level",
        "description": "Input Dcf source parameter. Maps to SBML symbol `input_dcf` and preserves the bundled default."
      }
    ],
    "outputs": [
      {
        "name": "inactive_receptor",
        "label": "Inactive Receptor",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.inactive_receptor",
        "description": "Inactive Receptor. Maps to SBML symbol `JAK1_gp130` and is emitted in native SBML units."
      },
      {
        "name": "total_phosphorylated_receptor",
        "label": "Total Phosphorylated Receptor",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.total_phosphorylated_receptor",
        "description": "Total Phosphorylated Receptor. Maps to SBML symbol `pJAK1_pgp130` and is emitted in native SBML units."
      },
      {
        "name": "unphosphorylated_stat3",
        "label": "Unphosphorylated STAT3",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.unphosphorylated_stat3",
        "description": "Unphosphorylated STAT3. Maps to SBML symbol `STAT3` and is emitted in native SBML units."
      },
      {
        "name": "state",
        "label": "Observable state",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.state"
      },
      {
        "name": "summary",
        "label": "Simulation summary",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.summary"
      },
      {
        "name": "species_labels",
        "label": "Observable labels",
        "maps_to": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.species_labels"
      }
    ]
  },
  "tags": [
    "signaling",
    "systems",
    "systems-biology",
    "sbml",
    "faithful",
    "biomodels_ebi",
    "cytokine-signaling",
    "interleukin-signaling",
    "smad"
  ],
  "title": "Zeilfelder2025 - Model for primary human hepatocytes (PHH) Lab",
  "models": [
    {
      "path": "models/core",
      "alias": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model"
    },
    {
      "path": "models/visualisation",
      "alias": "visualisation"
    }
  ],
  "wiring": [
    {
      "to": [
        "visualisation.signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model_state"
      ],
      "from": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.state"
    },
    {
      "to": [
        "visualisation.signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model_summary"
      ],
      "from": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.summary"
    },
    {
      "to": [
        "visualisation.signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model_species_labels"
      ],
      "from": "signaling_sbml_zeilfelder2025_model_for_primary_human_hepatocyt_model2503270002_model.species_labels"
    }
  ],
  "package": "zeilfelder2025-model-for-primary-human-hepatocyt",
  "runtime": {
    "duration": 1,
    "initial_inputs": {},
    "communication_step": 0.1
  },
  "version": "1.0.0",
  "description": "Clean Biosimulant lab for systems signaling model: Zeilfelder2025 - Model for primary human hepatocytes (PHH). Values are native SBML quantities; equations, parameters, and initial values remain in the bundled source file.",
  "schema_version": "2.0"
}