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Heldt et al. (2002) lumped circulation model used to study cardiovascular response to orthostatic stress (head-up tilt and lower body negative pressure).
Manifest
{
"io": {
"inputs": [
{
"name": "compliance_scale",
"maps_to": "heldt2002_orthostaticstress_circpbpk.compliance_scale"
},
{
"name": "heart_rate",
"maps_to": "heldt2002_orthostaticstress_circpbpk.heart_rate"
},
{
"name": "integration_step",
"maps_to": "heldt2002_orthostaticstress_circpbpk.integration_step"
},
{
"name": "peripheral_resistance_scale",
"maps_to": "heldt2002_orthostaticstress_circpbpk.peripheral_resistance_scale"
},
{
"name": "",
"maps_to": ""
}
],
"outputs": [
{
"name": "aortic_flow",
"maps_to": "heldt2002_orthostaticstress_circpbpk.aortic_flow"
},
{
"name": "aortic_pressure",
"maps_to": "heldt2002_orthostaticstress_circpbpk.aortic_pressure"
},
{
"name": "state",
"maps_to": "heldt2002_orthostaticstress_circpbpk.state"
},
{
"name": "summary",
"maps_to": "heldt2002_orthostaticstress_circpbpk.summary"
}
]
},
"title": "Heldt2002 Orthostatic Stress - Circulation PBPK Lab",
"models": [
{
"path": "models/core",
"alias": "heldt2002_orthostaticstress_circpbpk",
"parameters": {
"model_path": "data/MODEL1006230084.xml",
"integration_step": 0.05
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.heldt2002_orthostaticstress_circpbpk_aortic_flow"
],
"from": "heldt2002_orthostaticstress_circpbpk.aortic_flow"
},
{
"to": [
"visualisation.heldt2002_orthostaticstress_circpbpk_aortic_pressure"
],
"from": "heldt2002_orthostaticstress_circpbpk.aortic_pressure"
},
{
"to": [
"visualisation.heldt2002_orthostaticstress_circpbpk_state"
],
"from": "heldt2002_orthostaticstress_circpbpk.state"
},
{
"to": [
"visualisation.heldt2002_orthostaticstress_circpbpk_summary"
],
"from": "heldt2002_orthostaticstress_circpbpk.summary"
},
{
"to": [
"visualisation.heldt2002_orthostaticstress_circpbpk_visualisation_aux"
],
"from": "heldt2002_orthostaticstress_circpbpk.visualisation_aux"
}
],
"package": "heldt2002-circulation-pbpk",
"runtime": {
"duration": 60,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Heldt et al. (2002) lumped circulation model used to study cardiovascular response to orthostatic stress (head-up tilt and lower body negative pressure).",
"schema_version": "2.0"
}Runtime
Duration60
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageheldt2002-circulation-pbpk
Created2026-05-04
Updated2026-06-13
biomechanicscardiovascularcirculationsbmlbiomodels_ebifaithfulvisualisationheldt2002other