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This is a mathematical model of a growing tumor and its interaction with the immune system. The model consists of four populations: tumor cells, dendritic cells (representing the innate immune system).
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_tumor_observable_1",
"label": "Initial Unresolved Tumor Observable 1",
"units": "native source value",
"default": 1000000,
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_unresolved_tumor_observable_1",
"description": "Initial Unresolved Tumor Observable 1. Sets the initial value of bundled SBML species `T_Tumor_Cells`."
},
{
"name": "initial_cd8_t_cells",
"label": "Initial CD8 T Cells",
"units": "native source value",
"default": 10,
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_cd8_t_cells",
"description": "Initial CD8 T Cells. Sets the initial value of bundled SBML species `L_CD8_T_Cells`."
},
{
"name": "initial_cd4_t_cells",
"label": "Initial CD4 T Cells",
"units": "native source value",
"default": 5,
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_cd4_t_cells",
"description": "Initial CD4 T Cells. Sets the initial value of bundled SBML species `H_CD4_T_Cells`."
},
{
"name": "initial_dendritic_cells",
"label": "Initial Dendritic Cells",
"units": "native source value",
"default": 10,
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.initial_dendritic_cells",
"description": "Initial Dendritic Cells. Sets the initial value of bundled SBML species `D_Dendritic_Cells`."
},
{
"name": "tumor_death_cd8_rate",
"label": "Tumor Death CD8 Rate",
"units": "native source value",
"default": 4.2e-8,
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.tumor_death_cd8_rate",
"description": "Tumor Death CD8 Rate. Sets bundled SBML parameter `alpha_1`."
}
],
"outputs": [
{
"name": "unresolved_tumor_observable_1",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.unresolved_tumor_observable_1"
},
{
"name": "cd8_t_cells",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.cd8_t_cells"
},
{
"name": "cd4_t_cells",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.cd4_t_cells"
},
{
"name": "dendritic_cells",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.dendritic_cells"
},
{
"name": "state",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.species_labels"
}
]
},
"title": "Trisilowati2018 - Optimal control of tumor-immune system interaction with treatment Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_state"
],
"from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.state"
},
{
"to": [
"visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_summary"
],
"from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model_species_labels"
],
"from": "immunology_sbml_trisilowati2018_optimal_control_of_tumor_immune_biomd0000000880_model.species_labels"
}
],
"package": "trisilowati2018-optimal-control-of-tumor-immune-system-36348696",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a mathematical model of a growing tumor and its interaction with the immune system. The model consists of four populations: tumor cells, dendritic cells (representing the innate immune system).",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagetrisilowati2018-optimal-control-of-tumor-immune-system-36348696
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother