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This model represents the non-competitive binding of XIAP to Casapase-3 and Caspase-9. In other words, XIAP mediated feedback is abolished in this model.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_caspase_3",
"label": "Initial Caspase 3",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_3",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C3`."
},
{
"name": "initial_caspase_9",
"label": "Initial Caspase 9",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_9",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9`."
},
{
"name": "initial_caspase_9_xiap_complex",
"label": "Initial Caspase 9 Xiap Complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_9_xiap_complex",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9X`."
},
{
"name": "initial_caspase_9_cleaved_xiap_complex",
"label": "Initial Caspase 9 Cleaved Xiap Complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_9_cleaved_xiap_complex",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9_starX`."
},
{
"name": "initial_caspase_9_cleaved",
"label": "Initial Caspase 9 Cleaved",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_9_cleaved",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C9_star`."
},
{
"name": "initial_caspase_3_cleaved_xiap_complex",
"label": "Initial Caspase 3 Cleaved Xiap Complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.initial_caspase_3_cleaved_xiap_complex",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C3_starX`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.species_labels"
},
{
"name": "caspase_3",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_3"
},
{
"name": "caspase_9",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_9"
},
{
"name": "caspase_9_xiap_complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_9_xiap_complex"
},
{
"name": "caspase_9_cleaved_xiap_complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_9_cleaved_xiap_complex"
},
{
"name": "caspase_9_cleaved",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_9_cleaved"
},
{
"name": "caspase_3_cleaved_xiap_complex",
"maps_to": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.caspase_3_cleaved_xiap_complex"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Legewie2006 Apoptosis Nc Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model_state"
],
"from": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model_summary"
],
"from": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model_species_labels"
],
"from": "systemsbiology_sbml_legewie2006_apoptosis_nc_biomd0000000103_model.species_labels"
}
],
"package": "legewie2006-apoptosis-nc",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This model represents the non-competitive binding of XIAP to Casapase-3 and Caspase-9. In other words, XIAP mediated feedback is abolished in this model.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagelegewie2006-apoptosis-nc
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother