Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions Lab
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This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic.
Manifest
{
"io": {
"inputs": [
{
"name": "sigma_p_tilde_source_parameter",
"label": "Sigma p tilde source parameter",
"units": "native SBML value",
"default": 0.1,
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.sigma_p_tilde_source_parameter",
"description": "Sigma p tilde source parameter. Maps to bundled SBML parameter `sigma_p_tilde`."
}
],
"outputs": [
{
"name": "chemotherapy_level",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.chemotherapy_level",
"description": "C observable. Maps to SBML symbol `C`."
},
{
"name": "p",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.p",
"description": "P observable. Maps to SBML symbol `P`."
},
{
"name": "infected_tumor_cells",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.infected_tumor_cells",
"description": "I observable. Maps to SBML symbol `I`."
},
{
"name": "b",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.b",
"description": "B observable. Maps to SBML symbol `B`."
},
{
"name": "state",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.state",
"description": "Full raw SBML observable record for reproducibility and downstream visualisation."
},
{
"name": "summary",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.summary",
"description": "Change and peak summary across the simulated SBML observables."
},
{
"name": "species_labels",
"maps_to": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.species_labels",
"description": "Mapping from selected raw SBML observable symbols to display labels."
}
]
},
"tags": [
"biomodels_ebi",
"curated",
"faithful",
"immunology",
"immunotherapy",
"microenvironment",
"oncology",
"physiology",
"sbml",
"systemsbiology",
"tumor-growth"
],
"title": "Nikolaev2019 - Immunobiochemical reconstruction of influenza lung infection-melanoma skin cancer interactions Lab",
"models": [
{
"path": "models/core",
"alias": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_state"
],
"from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.state"
},
{
"to": [
"visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_summary"
],
"from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.summary"
},
{
"to": [
"visualisation.oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model_species_labels"
],
"from": "oncology_sbml_nikolaev2019_immunobiochemical_reconstruction_of_biomd0000000865_model.species_labels"
}
],
"package": "nikolaev2019-immunobiochemical-reconstruction-of-influe-df48d57f",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a mathematical mechanistic immunobiochemical model that incorporates T cell pathways that control programmed cell death protein 1 (PD-1) expression. A core component of the model is a kinetic.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagenikolaev2019-immunobiochemical-reconstruction-of-influe-df48d57f
Created2026-05-16
Updated2026-06-13
biomodels_ebicuratedfaithfulimmunologyimmunotherapymicroenvironmentoncologyphysiologysbmlsystemsbiologytumor-growthvisualisationother