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This is a mathematical model describing the dynamics of the immune response to hepatitis B, which takes into account contributions form innate and adaptive immune responses, as well as cytokines. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_unresolved_infection_observable_1",
"label": "Initial Unresolved Infection Observable 1",
"units": "native source value",
"default": 0.9,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.initial_unresolved_infection_observable_1",
"description": "Initial Unresolved Infection Observable 1. Sets the initial value of bundled SBML species `T`."
},
{
"name": "initial_unresolved_infection_observable_2",
"label": "Initial Unresolved Infection Observable 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.initial_unresolved_infection_observable_2",
"description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `I`."
},
{
"name": "initial_unresolved_infection_observable_3",
"label": "Initial Unresolved Infection Observable 3",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.initial_unresolved_infection_observable_3",
"description": "Initial Unresolved Infection Observable 3. Sets the initial value of bundled SBML species `F_1`."
},
{
"name": "initial_unresolved_infection_observable_4",
"label": "Initial Unresolved Infection Observable 4",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.initial_unresolved_infection_observable_4",
"description": "Initial Unresolved Infection Observable 4. Sets the initial value of bundled SBML species `F_2`."
},
{
"name": "initial_unresolved_infection_observable_5",
"label": "Initial Unresolved Infection Observable 5",
"units": "native source value",
"default": 0.1,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.initial_unresolved_infection_observable_5",
"description": "Initial Unresolved Infection Observable 5. Sets the initial value of bundled SBML species `N`."
},
{
"name": "uninfected_death_rate",
"label": "Uninfected Death Rate",
"units": "native source value",
"default": 0.003,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.uninfected_death_rate",
"description": "Uninfected Death Rate. Sets bundled SBML parameter `d`."
},
{
"name": "uninfected_infection_rate",
"label": "Uninfected Infection Rate",
"units": "native source value",
"default": 7,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.uninfected_infection_rate",
"description": "Uninfected Infection Rate. Sets bundled SBML parameter `beta`."
},
{
"name": "infected_death_rate",
"label": "Infected Death Rate",
"units": "native source value",
"default": 0.56,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.infected_death_rate",
"description": "Infected Death Rate. Sets bundled SBML parameter `delta`."
},
{
"name": "infected_killing_immune_rate",
"label": "Infected Killing Immune Rate",
"units": "native source value",
"default": 5,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.infected_killing_immune_rate",
"description": "Infected Killing Immune Rate. Sets bundled SBML parameter `mu_1`."
},
{
"name": "infected_killing_immune_rate_2",
"label": "Infected Killing Immune Rate 2",
"units": "native source value",
"default": 0.14,
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.infected_killing_immune_rate_2",
"description": "Infected Killing Immune Rate 2. Sets bundled SBML parameter `mu_2`."
}
],
"outputs": [
{
"name": "unresolved_infection_observable_1",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.unresolved_infection_observable_1"
},
{
"name": "unresolved_infection_observable_2",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.unresolved_infection_observable_2"
},
{
"name": "unresolved_infection_observable_3",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.unresolved_infection_observable_3"
},
{
"name": "unresolved_infection_observable_4",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.unresolved_infection_observable_4"
},
{
"name": "unresolved_infection_observable_5",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.unresolved_infection_observable_5"
},
{
"name": "state",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.species_labels"
}
]
},
"title": "FatehiChenar2018 - Mathematical model of immune response to hepatitis B Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model_state"
],
"from": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.state"
},
{
"to": [
"visualisation.immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model_summary"
],
"from": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model_species_labels"
],
"from": "immunology_sbml_fatehichenar2018_mathematical_model_of_immune_re_biomd0000000848_model.species_labels"
}
],
"package": "fatehichenar2018-mathematical-model-of-immune-response-64af4e26",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This is a mathematical model describing the dynamics of the immune response to hepatitis B, which takes into account contributions form innate and adaptive immune responses, as well as cytokines. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagefatehichenar2018-mathematical-model-of-immune-response-64af4e26
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother