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In this paper we present a model of the macrophageT lymphocyte interactions that generate ananti-tumor immune response. The modseple cifies i)induction of cytotoxic T lymphocytes, ii) antigenpresentat.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_tumor",
"label": "Initial Tumor",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.initial_tumor",
"description": "Initial Tumor. Sets the initial value of bundled SBML species `Tumor`."
},
{
"name": "initial_cytotoxic_t_lymphocyte_precursors",
"label": "Initial Cytotoxic T Lymphocyte Precursors",
"units": "native source value",
"default": 25,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.initial_cytotoxic_t_lymphocyte_precursors",
"description": "Initial Cytotoxic T Lymphocyte Precursors. Sets the initial value of bundled SBML species `CTLP`."
},
{
"name": "initial_cytotoxic_t_lymphocytes",
"label": "Initial Cytotoxic T Lymphocytes",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.initial_cytotoxic_t_lymphocytes",
"description": "Initial Cytotoxic T Lymphocytes. Sets the initial value of bundled SBML species `CTL`."
},
{
"name": "initial_helper_t_lymphocyte_precursors",
"label": "Initial Helper T Lymphocyte Precursors",
"units": "native source value",
"default": 15,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.initial_helper_t_lymphocyte_precursors",
"description": "Initial Helper T Lymphocyte Precursors. Sets the initial value of bundled SBML species `HTLP`."
},
{
"name": "initial_helper_t_lymphocytes",
"label": "Initial Helper T Lymphocytes",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.initial_helper_t_lymphocytes",
"description": "Initial Helper T Lymphocytes. Sets the initial value of bundled SBML species `HTL`."
},
{
"name": "kill_parameter",
"label": "Kill Parameter",
"units": "native source value",
"default": 10,
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.kill_parameter",
"description": "Kill Parameter. Sets bundled SBML parameter `Kill`."
}
],
"outputs": [
{
"name": "tumor",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.tumor"
},
{
"name": "cytotoxic_t_lymphocyte_precursors",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.cytotoxic_t_lymphocyte_precursors"
},
{
"name": "cytotoxic_t_lymphocytes",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.cytotoxic_t_lymphocytes"
},
{
"name": "helper_t_lymphocyte_precursors",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.helper_t_lymphocyte_precursors"
},
{
"name": "helper_t_lymphocytes",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.helper_t_lymphocytes"
},
{
"name": "state",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.species_labels"
}
]
},
"title": "Boer1985 - Macrophage T cell interaction in anti-tumor response Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model_state"
],
"from": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.state"
},
{
"to": [
"visualisation.immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model_summary"
],
"from": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model_species_labels"
],
"from": "immunology_sbml_boer1985_macrophage_t_cell_interaction_in_anti_t_model1911130003_model.species_labels"
}
],
"package": "boer1985-macrophage-t-cell-interaction-in-anti-tumor",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.1",
"description": "In this paper we present a model of the macrophageT lymphocyte interactions that generate ananti-tumor immune response. The modseple cifies i)induction of cytotoxic T lymphocytes, ii) antigenpresentat.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageboer1985-macrophage-t-cell-interaction-in-anti-tumor
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother