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Source-faithful physiology lab for Feedback control of T-cell receptor activation. Public controls and outputs are mapped to real source symbols for signalling physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_lck_active",
"label": "Initial Lck Active",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.initial_lck_active",
"description": "Initial value for Lck Active. Maps to source symbol `lck_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name.",
"accepted_units": [
"micromolar"
]
},
{
"name": "initial_lck_inactive",
"label": "Initial Lck Inactive",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.initial_lck_inactive",
"description": "Initial value for Lck Inactive. Maps to source symbol `lck_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name.",
"accepted_units": [
"micromolar"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.variable_labels"
},
{
"name": "lck_active",
"label": "Lck Active",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_active",
"description": "Lck Active. Maps to source symbol `lck_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "lck_inactive",
"label": "Lck Inactive",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_inactive",
"description": "Lck Inactive. Maps to source symbol `lck_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "phosphatase_active",
"label": "Phosphatase Active",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.phosphatase_active",
"description": "Phosphatase Active. Maps to source symbol `phosphatase_active`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "phosphatase_inactive",
"label": "Phosphatase Inactive",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.phosphatase_inactive",
"description": "Phosphatase Inactive. Maps to source symbol `phosphatase_inactive`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "lck_total",
"label": "Lck Total",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.lck_total",
"description": "Lck Total. Maps to source symbol `lck_total`. Units: micromolar. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "rate_constant_r_l",
"label": "Rate Constant R L (source r_l)",
"maps_to": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.rate_constant_r_l",
"description": "Rate Constant R L (source r_l). Maps to source symbol `r_l`. Units: micromolar_per_second. Naming evidence: units identify a rate constant but not a fuller biological role."
}
]
},
"title": "Physiome 4fb - Feedback Control T Cell Receptor Activation Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model",
"parameters": {
"model_path": "data/chan_SHP12004.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_state"
],
"from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.state"
},
{
"to": [
"visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_summary"
],
"from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_trajectory"
],
"from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model_variable_labels"
],
"from": "physiology_cellml_feedback_control_of_t_cell_receptor_activation_4fb_model.variable_labels"
}
],
"package": "physiome4fb-feedback-control-t-cell-receptor-activation",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Feedback control of T-cell receptor activation. Public controls and outputs are mapped to real source symbols for signalling physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagephysiome4fb-feedback-control-t-cell-receptor-activation
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother