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Single-model lab wrapper for Pomerening2005- Model of the Xenopus Cdc2/APC System. The cell-cycle oscillator includes an essential negative-feedback loop: Cdc2 activates the anaphase-promoting complex (APC), which leads to cyclin destruction and Cdc2 inactivation. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.
Manifest
{
"io": {
"inputs": [],
"outputs": [
{
"name": "cyclin_pool",
"label": "Cyclin pool",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cyclin_pool",
"description": "Tracks Cyclin pool in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cyclin_pool`."
},
{
"name": "cdc2cyclin",
"label": "Cdc2cyclin",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclin",
"description": "Tracks Cdc2cyclin in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclin`."
},
{
"name": "cdc2cyclinyp",
"label": "Cdc2cyclinyp",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclinyp",
"description": "Tracks Cdc2cyclinyp in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclinyp`."
},
{
"name": "cdc2cyclinyptp",
"label": "Cdc2cyclinyptp",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclinyptp",
"description": "Tracks Cdc2cyclinyptp in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclinyptp`."
},
{
"name": "cdc2cyclintp",
"label": "Cdc2cyclintp",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclintp",
"description": "Tracks Cdc2cyclintp in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2cyclintp`."
},
{
"name": "cdc2",
"label": "Cdc2",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2",
"description": "Tracks Cdc2 in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2`."
},
{
"name": "cdc2afcyclin",
"label": "Cdc2afcyclin",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2afcyclin",
"description": "Tracks Cdc2afcyclin in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2afcyclin`."
},
{
"name": "cdc2afcyclintp",
"label": "Cdc2afcyclintp",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2afcyclintp",
"description": "Tracks Cdc2afcyclintp in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2afcyclintp`."
},
{
"name": "cdc2af",
"label": "Cdc2af",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2af",
"description": "Tracks Cdc2af in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc2af`."
},
{
"name": "cdc25act",
"label": "Cdc25act",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc25act",
"description": "Tracks Cdc25act in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.cdc25act`."
},
{
"name": "wee1act",
"label": "Wee1act",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.wee1act",
"description": "Tracks Wee1act in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.wee1act`."
},
{
"name": "plxact",
"label": "Plxact",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.plxact",
"description": "Tracks Plxact in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.plxact`."
},
{
"name": "apcstar",
"label": "Apcstar",
"maps_to": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.apcstar",
"description": "Tracks Apcstar in the lab model via `cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.apcstar`."
}
]
},
"title": "Pomerening2005- Model of the Xenopus Cdc2/APC System Lab",
"models": [
{
"path": "models/core",
"alias": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model_state"
],
"from": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.state"
},
{
"to": [
"visualisation.cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model_summary"
],
"from": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.summary"
},
{
"to": [
"visualisation.cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model_species_labels"
],
"from": "cellcycle_sbml_pomerening2005_model_of_the_xenopus_cdc2_apc_sys_model2005150001_model.species_labels"
}
],
"package": "pomerening2005-xenopus-cdc2-apc",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Single-model lab wrapper for Pomerening2005- Model of the Xenopus Cdc2/APC System. The cell-cycle oscillator includes an essential negative-feedback loop: Cdc2 activates the anaphase-promoting complex (APC), which leads to cyclin destruction and Cdc2 inactivation. It can be used to explore cell-cycle regulation dynamics and compare checkpoint behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagepomerening2005-xenopus-cdc2-apc
Created2026-05-15
Updated2026-06-13
cellcyclesbmlbiomodels_ebifaithfulvisualisationother