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This model is from the article: A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_acoa",
"label": "Initial Acoa",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.initial_acoa",
"description": "Initial Acoa. Sets the initial value of bundled SBML species `s1`."
},
{
"name": "initial_hmg_coa",
"label": "Initial Hmg Coa",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.initial_hmg_coa",
"description": "Initial Hmg Coa. Sets the initial value of bundled SBML species `s2`."
},
{
"name": "initial_unresolved_signaling_observable_1",
"label": "Initial Unresolved Signaling Observable 1",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.initial_unresolved_signaling_observable_1",
"description": "Initial Unresolved Signaling Observable 1. Sets the initial value of bundled SBML species `s3`."
},
{
"name": "initial_unresolved_signaling_observable_1_2",
"label": "Initial Unresolved Signaling Observable 1 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.initial_unresolved_signaling_observable_1_2",
"description": "Initial Unresolved Signaling Observable 1 2. Sets the initial value of bundled SBML species `s4`."
},
{
"name": "initial_unresolved_signaling_observable_2",
"label": "Initial Unresolved Signaling Observable 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.initial_unresolved_signaling_observable_2",
"description": "Initial Unresolved Signaling Observable 2. Sets the initial value of bundled SBML species `s5`."
}
],
"outputs": [
{
"name": "acoa",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.acoa"
},
{
"name": "hmg_coa",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.hmg_coa"
},
{
"name": "unresolved_signaling_observable_1",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.unresolved_signaling_observable_1"
},
{
"name": "unresolved_signaling_observable_1_2",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.unresolved_signaling_observable_1_2"
},
{
"name": "unresolved_signaling_observable_2",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.unresolved_signaling_observable_2"
},
{
"name": "state",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_model1207300000_url_xml_model1207300000_model.species_labels"
}
]
},
"title": "MODEL1207300000 url.xml Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_model1207300000_url_xml_model1207300000_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_model1207300000_url_xml_model1207300000_model_state"
],
"from": "immunology_sbml_model1207300000_url_xml_model1207300000_model.state"
},
{
"to": [
"visualisation.immunology_sbml_model1207300000_url_xml_model1207300000_model_summary"
],
"from": "immunology_sbml_model1207300000_url_xml_model1207300000_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_model1207300000_url_xml_model1207300000_model_species_labels"
],
"from": "immunology_sbml_model1207300000_url_xml_model1207300000_model.species_labels"
}
],
"package": "model1207300000-url-xml-model1207300000-url-xml",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This model is from the article: A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagemodel1207300000-url-xml-model1207300000-url-xml
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother