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Source-faithful physiology lab for Notch signaling pathway. Public controls and outputs are mapped to real source symbols for signalling physiology.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_dll1",
"label": "Initial Dll1",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.initial_dll1",
"description": "Initial value for Dll1. Maps to source symbol `Dll1`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name.",
"accepted_units": [
"nM"
]
},
{
"name": "initial_hes7_c",
"label": "Initial Hes7 C",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.initial_hes7_c",
"description": "Initial value for Hes7 C. Maps to source symbol `Hes7_c`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name.",
"accepted_units": [
"nM"
]
}
],
"outputs": [
{
"name": "state",
"label": "Selected Source State",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.state"
},
{
"name": "summary",
"label": "Simulation Summary",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.summary"
},
{
"name": "trajectory",
"label": "Source Trajectory",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.trajectory"
},
{
"name": "variable_labels",
"label": "Observable Labels",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.variable_labels"
},
{
"name": "dll1",
"label": "Dll1",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.dll1",
"description": "Dll1. Maps to source symbol `Dll1`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "hes7_c",
"label": "Hes7 C",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.hes7_c",
"description": "Hes7 C. Maps to source symbol `Hes7_c`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "hes7_n",
"label": "Hes7 N",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.hes7_n",
"description": "Hes7 N. Maps to source symbol `Hes7_n`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "lfng",
"label": "Lfng",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.lfng",
"description": "Lfng. Maps to source symbol `Lfng`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "m_hes7_c",
"label": "M Hes7 C",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.m_hes7_c",
"description": "M Hes7 C. Maps to source symbol `mHes7_c`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
},
{
"name": "m_hes7_n",
"label": "M Hes7 N",
"maps_to": "physiology_cellml_notch_signaling_pathway_1cd_model.m_hes7_n",
"description": "M Hes7 N. Maps to source symbol `mHes7_n`. Units: nM. Naming evidence: source symbol, component, or units provide a direct public name."
}
]
},
"title": "Physiome 1cd - Notch Signaling Pathway Lab",
"models": [
{
"path": "models/core",
"alias": "physiology_cellml_notch_signaling_pathway_1cd_model",
"parameters": {
"model_path": "data/Notch_1_Wang.cellml",
"integration_step": 0.01
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.physiology_cellml_notch_signaling_pathway_1cd_model_state"
],
"from": "physiology_cellml_notch_signaling_pathway_1cd_model.state"
},
{
"to": [
"visualisation.physiology_cellml_notch_signaling_pathway_1cd_model_summary"
],
"from": "physiology_cellml_notch_signaling_pathway_1cd_model.summary"
},
{
"to": [
"visualisation.physiology_cellml_notch_signaling_pathway_1cd_model_trajectory"
],
"from": "physiology_cellml_notch_signaling_pathway_1cd_model.trajectory"
},
{
"to": [
"visualisation.physiology_cellml_notch_signaling_pathway_1cd_model_variable_labels"
],
"from": "physiology_cellml_notch_signaling_pathway_1cd_model.variable_labels"
}
],
"package": "physiome1cd-notch-signaling-pathway",
"runtime": {
"duration": 0.01,
"settle_steps": 1,
"initial_inputs": {},
"communication_step": 0.01
},
"version": "1.0.0",
"description": "Source-faithful physiology lab for Notch signaling pathway. Public controls and outputs are mapped to real source symbols for signalling physiology.",
"schema_version": "2.0"
}Runtime
Duration0.01
Comms Step0.01
Settle Steps1
Runs
Total0
Completed0
Failed0
Metadata
Packagephysiome1cd-notch-signaling-pathway
Created2026-05-23
Updated2026-06-13
physiologycellmlphysiomefaithfulvisualisationother