About lab
One published Lab
Build with this Lab. Run it anywhere.
Use the same immutable release locally or through managed cloud execution, with its exact version and provenance preserved.
Preparing exact examples…
Chickarmane2008 - Stem cell lineage - NANOG GATA-6 switch In this work, a dynamical model of lineage determination based upon a minimal circuit, as discussed in PMID: 17215298 , which contains the Oct. It can be used to explore systemsbiology chickarmane2008 stem cell lineage nanog dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_target_gene",
"label": "Initial Target Gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_target_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `targetGene`."
},
{
"name": "initial_sox2_gene",
"label": "Initial Sox2 Gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_sox2_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `SOX2_Gene`."
},
{
"name": "initial_protein",
"label": "Initial Protein",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_protein",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `Protein`."
},
{
"name": "initial_oct4_gene",
"label": "Initial Oct4 Gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_oct4_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `OCT4_Gene`."
},
{
"name": "initial_nanog_gene",
"label": "Initial Nanog Gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_nanog_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `NANOG_Gene`."
},
{
"name": "initial_gcnf_gene",
"label": "Initial Gcnf Gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.initial_gcnf_gene",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `GCNF_Gene`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.species_labels"
},
{
"name": "target_gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.target_gene"
},
{
"name": "sox2_gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.sox2_gene"
},
{
"name": "protein",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.protein"
},
{
"name": "oct4_gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.oct4_gene"
},
{
"name": "nanog_gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.nanog_gene"
},
{
"name": "gcnf_gene",
"maps_to": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.gcnf_gene"
}
]
},
"tags": [
"development",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Chickarmane2008 Stem Cell Lineage Nanog Gata 6 Switch Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model_state"
],
"from": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model_summary"
],
"from": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model_species_labels"
],
"from": "systemsbiology_sbml_chickarmane2008_stem_cell_lineage_nanog_gata_6_s_biomd0000000210_model.species_labels"
}
],
"package": "chickarmane2008-stem-cell-lineage-nanog-gata-6-switch",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "Chickarmane2008 - Stem cell lineage - NANOG GATA-6 switch In this work, a dynamical model of lineage determination based upon a minimal circuit, as discussed in PMID: 17215298 , which contains the Oct. It can be used to explore systemsbiology chickarmane2008 stem cell lineage nanog dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packagechickarmane2008-stem-cell-lineage-nanog-gata-6-switch
Created2026-05-17
Updated2026-06-13
developmentsystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother