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The model reproduces Fig 3 of the paper. It can be used to explore systemsbiology romond1999 cellcycle BioModels0000000207 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cyclin_b",
"label": "Initial Cyclin B",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_cyclin_b",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C1`."
},
{
"name": "initial_cdk1",
"label": "Initial Cdk1",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_cdk1",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M1`."
},
{
"name": "initial_ubiquitin_ligase",
"label": "Initial Ubiquitin Ligase",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_ubiquitin_ligase",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `X1`."
},
{
"name": "initial_cyclin_e",
"label": "Initial Cyclin E",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_cyclin_e",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C2`."
},
{
"name": "initial_cdk2",
"label": "Initial Cdk2",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_cdk2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `M2`."
},
{
"name": "initial_ubiquitin_ligase_2",
"label": "Initial Ubiquitin Ligase 2",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.initial_ubiquitin_ligase_2",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `X2`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.species_labels"
},
{
"name": "cyclin_b",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.cyclin_b"
},
{
"name": "cdk1",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.cdk1"
},
{
"name": "ubiquitin_ligase",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.ubiquitin_ligase"
},
{
"name": "cyclin_e",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.cyclin_e"
},
{
"name": "cdk2",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.cdk2"
},
{
"name": "ubiquitin_ligase_2",
"maps_to": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.ubiquitin_ligase_2"
}
]
},
"tags": [
"cellcycle",
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Romond1999 Cellcycle Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model_state"
],
"from": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model_summary"
],
"from": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model_species_labels"
],
"from": "systemsbiology_sbml_romond1999_cellcycle_biomd0000000207_model.species_labels"
}
],
"package": "romond1999-cellcycle",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "The model reproduces Fig 3 of the paper. It can be used to explore systemsbiology romond1999 cellcycle BioModels0000000207 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageromond1999-cellcycle
Created2026-05-17
Updated2026-06-13
cellcyclesystemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother