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The model is the second model of the publication 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses to Helicobacter pylori infection' published in Plo. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_cx3cr1_receptor",
"label": "Initial Cx3cr1 Receptor",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_cx3cr1_receptor",
"description": "Initial Cx3cr1 Receptor. Sets the initial value of bundled SBML species `s1`."
},
{
"name": "initial_unresolved_infection_observable_1",
"label": "Initial Unresolved Infection Observable 1",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_unresolved_infection_observable_1",
"description": "Initial Unresolved Infection Observable 1. Sets the initial value of bundled SBML species `s2`."
},
{
"name": "initial_erk",
"label": "Initial ERK",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_erk",
"description": "Initial ERK. Sets the initial value of bundled SBML species `s3`."
},
{
"name": "initial_unresolved_infection_observable_2",
"label": "Initial Unresolved Infection Observable 2",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.initial_unresolved_infection_observable_2",
"description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `s4`."
}
],
"outputs": [
{
"name": "cx3cr1_receptor",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.cx3cr1_receptor"
},
{
"name": "unresolved_infection_observable_1",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_1"
},
{
"name": "erk",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.erk"
},
{
"name": "unresolved_infection_observable_2",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_2"
},
{
"name": "unresolved_infection_observable_3",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.unresolved_infection_observable_3"
},
{
"name": "state",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.species_labels"
}
]
},
"title": "Leber2016 - Regulatory macrophage differentiation - H.pylori infection Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_state"
],
"from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.state"
},
{
"to": [
"visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_summary"
],
"from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model_species_labels"
],
"from": "immunology_sbml_leber2016_regulatory_macrophage_differentiation_model1611160001_model.species_labels"
}
],
"package": "leber2016-regulatory-macrophage-differentiation-h-pylor-fc116419",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "The model is the second model of the publication 'Modeling the role of lanthionine synthetase C-like 2 (LANCL2) in the modulation of immune responses to Helicobacter pylori infection' published in Plo. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageleber2016-regulatory-macrophage-differentiation-h-pylor-fc116419
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother