Lavigne2021 - Non-spatial model of viral infection dynamics and interferon response of well-mixed viral infection Lab
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This ordinary differential equation model is described in the following article:'Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_infected_cells_antiviral",
"label": "Initial Infected Cells Antiviral",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.initial_infected_cells_antiviral",
"description": "Initial Infected Cells Antiviral. Sets the initial value of bundled SBML species `Infected_cells_antiviral`."
},
{
"name": "initial_infected_cells",
"label": "Initial Infected Cells",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.initial_infected_cells",
"description": "Initial Infected Cells. Sets the initial value of bundled SBML species `Infected_cells`."
},
{
"name": "initial_interferon",
"label": "Initial Interferon",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.initial_interferon",
"description": "Initial Interferon. Sets the initial value of bundled SBML species `IFN`."
},
{
"name": "initial_target_cells",
"label": "Initial Target Cells",
"units": "native source value",
"default": 400000000,
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.initial_target_cells",
"description": "Initial Target Cells. Sets the initial value of bundled SBML species `Target_cells`."
},
{
"name": "initial_refractory_cells",
"label": "Initial Refractory Cells",
"units": "native source value",
"default": 0,
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.initial_refractory_cells",
"description": "Initial Refractory Cells. Sets the initial value of bundled SBML species `Refractory_cells`."
}
],
"outputs": [
{
"name": "infected_cells_antiviral",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.infected_cells_antiviral"
},
{
"name": "infected_cells",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.infected_cells"
},
{
"name": "interferon",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.interferon"
},
{
"name": "target_cells",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.target_cells"
},
{
"name": "refractory_cells",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.refractory_cells"
},
{
"name": "state",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.species_labels"
}
]
},
"title": "Lavigne2021 - Non-spatial model of viral infection dynamics and interferon response of well-mixed viral infection Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model_state"
],
"from": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.state"
},
{
"to": [
"visualisation.immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model_summary"
],
"from": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model_species_labels"
],
"from": "immunology_sbml_lavigne2021_non_spatial_model_of_viral_infection_biomd0000001021_model.species_labels"
}
],
"package": "lavigne2021-non-spatial-model-of-viral-infection-dynamics",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "This ordinary differential equation model is described in the following article:'Autocrine and paracrine interferon signalling as ‘ring vaccination’ and ‘contact tracing’ strategies to suppress virus. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packagelavigne2021-non-spatial-model-of-viral-infection-dynamics
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother