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This a model from the article: A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease Bruce P Ayati, Claire M Edwards, Glenn F Webb and John P Wiksw. It can be used to explore systemsbiology ayati2010 boneremodelingdynamics normalcondition BioModels0000000401 dynamics and compare simulation behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_osteoblasts",
"label": "Initial Osteoblasts",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.initial_osteoblasts",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `B`."
},
{
"name": "initial_bone_mass",
"label": "Initial Bone Mass",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.initial_bone_mass",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `z`."
},
{
"name": "initial_osteoclasts",
"label": "Initial Osteoclasts",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.initial_osteoclasts",
"description": "Source state initial condition exposed as a model-specific control because no explicit intervention parameter is identifiable. Maps to SBML symbol `C`."
}
],
"outputs": [
{
"name": "state",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.state"
},
{
"name": "summary",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.summary"
},
{
"name": "species_labels",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.species_labels"
},
{
"name": "osteoblasts",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.osteoblasts"
},
{
"name": "bone_mass",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.bone_mass"
},
{
"name": "osteoclasts",
"maps_to": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.osteoclasts"
}
]
},
"tags": [
"systemsbiology",
"sbml",
"biomodels_ebi",
"faithful",
"curated"
],
"title": "Ayati2010 Boneremodelingdynamics Normalcondition Lab",
"models": [
{
"path": "models/core",
"alias": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model_state"
],
"from": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.state"
},
{
"to": [
"visualisation.systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model_summary"
],
"from": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.summary"
},
{
"to": [
"visualisation.systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model_species_labels"
],
"from": "systemsbiology_sbml_ayati2010_boneremodelingdynamics_normalcondition_biomd0000000401_model.species_labels"
}
],
"package": "ayati2010-boneremodelingdynamics-normalcondition",
"runtime": {
"duration": 1,
"initial_inputs": {},
"communication_step": 0.1
},
"version": "1.0.0",
"description": "This a model from the article: A mathematical model of bone remodeling dynamics for normal bone cell populations and myeloma bone disease Bruce P Ayati, Claire M Edwards, Glenn F Webb and John P Wiksw. It can be used to explore systemsbiology ayati2010 boneremodelingdynamics normalcondition BioModels0000000401 dynamics and compare simulation behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration1
Comms Step0.1
Runs
Total0
Completed0
Failed0
Metadata
Packageayati2010-boneremodelingdynamics-normalcondition
Created2026-05-17
Updated2026-06-13
systemsbiologysbmlbiomodels_ebifaithfulcuratedvisualisationother