Guyton1972 Heart Rate Stroke Volume Lab

{
  "io": {
    "inputs": [
      {
        "name": "integration_step",
        "maps_to": "guyton1972_heart_rate_stroke_volume_core.integration_step"
      },
      {
        "name": "parameter_overrides",
        "maps_to": "guyton1972_heart_rate_stroke_volume_core.parameter_overrides"
      },
      {
        "name": "initial_conditions",
        "maps_to": "guyton1972_heart_rate_stroke_volume_core.initial_conditions"
      }
    ],
    "outputs": [
      {
        "name": "scenario_metadata",
        "maps_to": "guyton1972_heart_rate_stroke_volume_scenario.scenario_metadata"
      },
      {
        "name": "state",
        "maps_to": "guyton1972_heart_rate_stroke_volume_core.state"
      },
      {
        "name": "run_summary",
        "maps_to": "guyton1972_heart_rate_stroke_volume_viz.run_summary"
      }
    ]
  },
  "title": "Guyton1972 Heart Rate Stroke Volume Lab",
  "models": [
    {
      "path": "models/scenario",
      "alias": "guyton1972_heart_rate_stroke_volume_scenario",
      "parameters": {
        "schedule": {
          "cardiac_output": {
            "unit": "dimensionless",
            "label": "cardiac output",
            "active": false,
            "baseline": 4.9943,
            "recovery": 4.9943,
            "challenge": 4.9943,
            "description": "Scenario-controlled cardiac output value."
          },
          "autonomic_drive": {
            "unit": "dimensionless",
            "label": "autonomic drive",
            "active": false,
            "baseline": 1.3,
            "recovery": 1.3,
            "challenge": 1.3,
            "description": "Scenario-controlled autonomic drive value."
          },
          "right_atrial_pressure": {
            "unit": "dimensionless",
            "label": "right atrial pressure",
            "active": true,
            "baseline": 0.00852183,
            "recovery": 0.00852183,
            "challenge": 0.010226195999999998,
            "description": "Scenario-controlled right atrial pressure value."
          }
        },
        "scenario_name": "Pressure-load challenge",
        "baseline_until": 2.5,
        "challenge_until": 7.5,
        "scenario_description": "Baseline is followed by a right atrial pressure challenge and recovery period."
      }
    },
    {
      "path": "./models/core",
      "alias": "guyton1972_heart_rate_stroke_volume_core",
      "parameters": {
        "model_path": "data/MODEL0911270006.xml",
        "integration_step": 0.01
      }
    },
    {
      "path": "./models/viz",
      "alias": "guyton1972_heart_rate_stroke_volume_viz",
      "parameters": {
        "lab_title": "Guyton1972 Heart Rate Stroke Volume",
        "lab_question": "How do heart rate and stroke volume respond?",
        "integration_step": 0.01
      }
    }
  ],
  "wiring": [
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_core.autonomic_drive"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_scenario.autonomic_drive"
    },
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_core.right_atrial_pressure"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_scenario.right_atrial_pressure"
    },
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_core.cardiac_output"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_scenario.cardiac_output"
    },
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_viz.scenario_metadata"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_scenario.scenario_metadata"
    },
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_viz.state"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_core.state"
    },
    {
      "to": [
        "guyton1972_heart_rate_stroke_volume_viz.species_labels"
      ],
      "from": "guyton1972_heart_rate_stroke_volume_core.species_labels"
    }
  ],
  "package": "guyton1972-heart-rate-stroke-volume",
  "runtime": {
    "duration": 10,
    "initial_inputs": {
      "guyton1972_heart_rate_stroke_volume_core": {
        "integration_step": 0.01,
        "initial_conditions": {
          "payload": {}
        },
        "parameter_overrides": {
          "payload": {}
        }
      }
    },
    "communication_step": 0.01
  },
  "version": "1.0.0",
  "description": "Two-model lab for Guyton1972 Heart Rate Stroke Volume: a core SBML simulator wired into a dedicated visualization sub-model that turns the raw state into friendly timeseries and a plain-language summary. This a model from the article: Circulation: overall regulation. It can be used to explore cardiac dynamics and compare response patterns across conditions.",
  "schema_version": "2.0"
}