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Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under.
Manifest
{
"io": {
"inputs": [
{
"name": "oral_toxicant_input",
"label": "Oral Toxicant Input",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.oral_toxicant_input"
},
{
"name": "iv_toxicant_input",
"label": "IV Toxicant Input",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.iv_toxicant_input"
},
{
"name": "initial_plasma_toxicant_burden",
"label": "Initial Plasma Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.initial_plasma_toxicant_burden"
},
{
"name": "urinary_elimination_rate",
"label": "Urinary Elimination Rate",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.urinary_elimination_rate"
},
{
"name": "free_fraction",
"label": "Free Fraction",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.free_fraction"
}
],
"outputs": [
{
"name": "state",
"label": "Tracked source state",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.state"
},
{
"name": "summary",
"label": "Simulation summary",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.summary"
},
{
"name": "species_labels",
"label": "Observable labels",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.species_labels"
},
{
"name": "plasma_toxicant_burden",
"label": "Plasma Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.plasma_toxicant_burden"
},
{
"name": "liver_toxicant_burden",
"label": "Liver Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.liver_toxicant_burden"
},
{
"name": "kidney_toxicant_burden",
"label": "Kidney Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.kidney_toxicant_burden"
},
{
"name": "gut_toxicant_burden",
"label": "Gut Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.gut_toxicant_burden"
},
{
"name": "fat_toxicant_burden",
"label": "Fat Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.fat_toxicant_burden"
},
{
"name": "skin_toxicant_burden",
"label": "Skin Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.skin_toxicant_burden"
},
{
"name": "urine_toxicant_burden",
"label": "Urine Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.urine_toxicant_burden"
},
{
"name": "filtrate_toxicant_burden",
"label": "Filtrate Toxicant Burden",
"maps_to": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.filtrate_toxicant_burden"
}
]
},
"tags": [
"pharmacology",
"toxicology",
"pharmacokinetics",
"pbpk",
"physiology",
"sbml",
"tellurium",
"faithful",
"biomodels_ebi"
],
"title": "Loccisano2011-pharmacokinetics of PFOA and PFOS in the monkey Lab",
"models": [
{
"path": "models/core",
"alias": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model",
"parameters": {
"model_path": "data/MODEL2003190002.xml",
"integration_step": 0.1
}
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model_state"
],
"from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.state"
},
{
"to": [
"visualisation.pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model_summary"
],
"from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.summary"
},
{
"to": [
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],
"from": "pharmacology_sbml_loccisano2011_pharmacokinetics_of_pfoa_and_pfos_model2003190002_model.species_labels"
}
],
"package": "loccisano2011-pfoa-pfos-pk",
"runtime": {
"duration": 24,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "Perfluoroalkyl acid carboxylates and sulfonates (PFAAs) have many consumer and industrial applications. The persistence and widespread distribution of these compounds in humans have brought them under.",
"schema_version": "2.0"
}Runtime
Duration24
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageloccisano2011-pfoa-pfos-pk
Created2026-05-16
Updated2026-06-13
pharmacologytoxicologypharmacokineticspbpkphysiologysbmltelluriumfaithfulbiomodels_ebivisualisationother