Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection Lab
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In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.
Manifest
{
"io": {
"inputs": [
{
"name": "initial_lpg_toll_like_receptor_complex",
"label": "Initial Lpg Toll Like Receptor Complex",
"units": "MWBUILTINUNIT_molecule",
"default": 1000,
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_lpg_toll_like_receptor_complex",
"description": "Initial Lpg Toll Like Receptor Complex. Sets the initial value of bundled SBML species `mw3d4055f8_c490_4463_911f_eed820b1323c`."
},
{
"name": "initial_unresolved_infection_observable_2",
"label": "Initial Unresolved Infection Observable 2",
"units": "MWBUILTINUNIT_molecule",
"default": 3980,
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_unresolved_infection_observable_2",
"description": "Initial Unresolved Infection Observable 2. Sets the initial value of bundled SBML species `mwc4164d07_8269_4b39_b8af_6c1b22eee1ea`."
},
{
"name": "initial_irak1_irak4_complex",
"label": "Initial Irak1 Irak4 Complex",
"units": "MWBUILTINUNIT_molecule",
"default": 2000,
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.initial_irak1_irak4_complex",
"description": "Initial Irak1 Irak4 Complex. Sets the initial value of bundled SBML species `mw21d5a961_4d66_4509_88cd_c983fa74e314`."
}
],
"outputs": [
{
"name": "unresolved_infection_observable_1",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.unresolved_infection_observable_1"
},
{
"name": "toll_like_receptor",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.toll_like_receptor"
},
{
"name": "lpg_toll_like_receptor_complex",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.lpg_toll_like_receptor_complex"
},
{
"name": "unresolved_infection_observable_2",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.unresolved_infection_observable_2"
},
{
"name": "irak1_irak4_complex",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.irak1_irak4_complex"
},
{
"name": "state",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.state"
},
{
"name": "summary",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.summary"
},
{
"name": "species_labels",
"maps_to": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.species_labels"
}
]
},
"title": "Immunological Healthy State Model of Sphingolipids with IL-6/IL-17/IL-23 immune axis in L.major infection Lab",
"models": [
{
"path": "models/core",
"alias": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model"
},
{
"path": "models/visualisation",
"alias": "visualisation"
}
],
"wiring": [
{
"to": [
"visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_state"
],
"from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.state"
},
{
"to": [
"visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_summary"
],
"from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.summary"
},
{
"to": [
"visualisation.immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model_species_labels"
],
"from": "immunology_sbml_immunological_healthy_state_model_of_sphingolipi_model2301110002_model.species_labels"
}
],
"package": "immunological-healthy-state-immunological-healthy-state-4e19adc9",
"runtime": {
"duration": 10,
"initial_inputs": {},
"communication_step": 1
},
"version": "1.0.0",
"description": "In Healthy State, we demonstrated the controlled expression of sphingolipids and the controlled IL-6,IL-17,IL-23 cytokines signalling via SOCS3 mediated regulation. It can be used to explore immune response dynamics and compare pathway-level behavior across conditions.",
"schema_version": "2.0"
}Runtime
Duration10
Comms Step1
Runs
Total0
Completed0
Failed0
Metadata
Packageimmunological-healthy-state-immunological-healthy-state-4e19adc9
Created2026-05-15
Updated2026-06-13
immunologysbmlbiomodels_ebifaithfulcuratedvisualisationother